Serum Methylarginines and Spirometry-Measured Lung Function in Older Adults

Mark A. McEvoy, Peter W. Schofield, Wayne T. Smith, Kingsley Agho, Arduino A. Mangoni, Roy L. Soiza, Roseanne Peel, Stephen J. Hancock, Ciriaco Carru, Angelo Zinellu, John R. Attia

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Abstract

RATIONALE: Methylarginines are endogenous nitric oxide synthase inhibitors that have been implicated in animal models of lung disease but have not previously been examined for their association with spirometric measures of lung function in humans.

OBJECTIVES: This study measured serum concentrations of asymmetric and symmetric dimethylarginine in a representative sample of older community-dwelling adults and determined their association with spirometric lung function measures.

METHODS: Data on clinical, lifestyle, and demographic characteristics, methylated arginines, and L-arginine (measured using LC-MS/MS) were collected from a population-based sample of older Australian adults from the Hunter Community Study. The five key lung function measures included as outcomes were Forced Expiratory Volume in 1 second, Forced Vital Capacity, Forced Expiratory Volume in 1 second to Forced Vital Capacity ratio, Percent Predicted Forced Expiratory Volume in 1 second, and Percent Predicted Forced Vital Capacity.

MEASUREMENTS AND MAIN RESULTS: In adjusted analyses there were statistically significant independent associations between a) higher asymmetric dimethylarginine, lower Forced Expiratory Volume in 1 second and lower Forced Vital Capacity; and b) lower L-arginine/asymmetric dimethylarginine ratio, lower Forced Expiratory Volume in 1 second, lower Percent Predicted Forced Expiratory Volume in 1 second and lower Percent Predicted Forced Vital Capacity. By contrast, no significant associations were observed between symmetric dimethylarginine and lung function.

CONCLUSIONS: After adjusting for clinical, demographic, biochemical, and pharmacological confounders, higher serum asymmetric dimethylarginine was independently associated with a reduction in key measures of lung function. Further research is needed to determine if methylarginines predict the decline in lung function.

Original languageEnglish
Article numbere58390
Pages (from-to)1-11
Number of pages11
JournalPloS ONE
Volume8
Issue number5
DOIs
Publication statusPublished - 15 May 2013

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lung function
Spirometry
Forced Expiratory Volume
Vital Capacity
Lung
Serum
arginine
Arginine
Demography
Association reactions
Independent Living
Pulmonary diseases
sociodemographic characteristics
nitric oxide synthase
Nitric Oxide Synthase
respiratory tract diseases
Lung Diseases
lifestyle
Life Style
Animals

Cite this

McEvoy, M. A., Schofield, P. W., Smith, W. T., Agho, K., Mangoni, A. A., Soiza, R. L., ... Attia, J. R. (2013). Serum Methylarginines and Spirometry-Measured Lung Function in Older Adults. PloS ONE, 8(5), 1-11. [e58390]. https://doi.org/10.1371/journal.pone.0058390

Serum Methylarginines and Spirometry-Measured Lung Function in Older Adults. / McEvoy, Mark A.; Schofield, Peter W.; Smith, Wayne T.; Agho, Kingsley; Mangoni, Arduino A.; Soiza, Roy L.; Peel, Roseanne; Hancock, Stephen J.; Carru, Ciriaco; Zinellu, Angelo; Attia, John R.

In: PloS ONE, Vol. 8, No. 5, e58390, 15.05.2013, p. 1-11.

Research output: Contribution to journalArticle

McEvoy, MA, Schofield, PW, Smith, WT, Agho, K, Mangoni, AA, Soiza, RL, Peel, R, Hancock, SJ, Carru, C, Zinellu, A & Attia, JR 2013, 'Serum Methylarginines and Spirometry-Measured Lung Function in Older Adults', PloS ONE, vol. 8, no. 5, e58390, pp. 1-11. https://doi.org/10.1371/journal.pone.0058390
McEvoy MA, Schofield PW, Smith WT, Agho K, Mangoni AA, Soiza RL et al. Serum Methylarginines and Spirometry-Measured Lung Function in Older Adults. PloS ONE. 2013 May 15;8(5):1-11. e58390. https://doi.org/10.1371/journal.pone.0058390
McEvoy, Mark A. ; Schofield, Peter W. ; Smith, Wayne T. ; Agho, Kingsley ; Mangoni, Arduino A. ; Soiza, Roy L. ; Peel, Roseanne ; Hancock, Stephen J. ; Carru, Ciriaco ; Zinellu, Angelo ; Attia, John R. / Serum Methylarginines and Spirometry-Measured Lung Function in Older Adults. In: PloS ONE. 2013 ; Vol. 8, No. 5. pp. 1-11.
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abstract = "RATIONALE: Methylarginines are endogenous nitric oxide synthase inhibitors that have been implicated in animal models of lung disease but have not previously been examined for their association with spirometric measures of lung function in humans.OBJECTIVES: This study measured serum concentrations of asymmetric and symmetric dimethylarginine in a representative sample of older community-dwelling adults and determined their association with spirometric lung function measures.METHODS: Data on clinical, lifestyle, and demographic characteristics, methylated arginines, and L-arginine (measured using LC-MS/MS) were collected from a population-based sample of older Australian adults from the Hunter Community Study. The five key lung function measures included as outcomes were Forced Expiratory Volume in 1 second, Forced Vital Capacity, Forced Expiratory Volume in 1 second to Forced Vital Capacity ratio, Percent Predicted Forced Expiratory Volume in 1 second, and Percent Predicted Forced Vital Capacity.MEASUREMENTS AND MAIN RESULTS: In adjusted analyses there were statistically significant independent associations between a) higher asymmetric dimethylarginine, lower Forced Expiratory Volume in 1 second and lower Forced Vital Capacity; and b) lower L-arginine/asymmetric dimethylarginine ratio, lower Forced Expiratory Volume in 1 second, lower Percent Predicted Forced Expiratory Volume in 1 second and lower Percent Predicted Forced Vital Capacity. By contrast, no significant associations were observed between symmetric dimethylarginine and lung function.CONCLUSIONS: After adjusting for clinical, demographic, biochemical, and pharmacological confounders, higher serum asymmetric dimethylarginine was independently associated with a reduction in key measures of lung function. Further research is needed to determine if methylarginines predict the decline in lung function.",
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note = "Funding: Funding provided by the University of Newcastle Strategic Initiative Fund. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Acknowledgments We are grateful to The University of Newcastle for funding and to the men and women of the Hunter region who provided the information recorded.",
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AU - Schofield, Peter W.

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AU - Agho, Kingsley

AU - Mangoni, Arduino A.

AU - Soiza, Roy L.

AU - Peel, Roseanne

AU - Hancock, Stephen J.

AU - Carru, Ciriaco

AU - Zinellu, Angelo

AU - Attia, John R.

N1 - Funding: Funding provided by the University of Newcastle Strategic Initiative Fund. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Acknowledgments We are grateful to The University of Newcastle for funding and to the men and women of the Hunter region who provided the information recorded.

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N2 - RATIONALE: Methylarginines are endogenous nitric oxide synthase inhibitors that have been implicated in animal models of lung disease but have not previously been examined for their association with spirometric measures of lung function in humans.OBJECTIVES: This study measured serum concentrations of asymmetric and symmetric dimethylarginine in a representative sample of older community-dwelling adults and determined their association with spirometric lung function measures.METHODS: Data on clinical, lifestyle, and demographic characteristics, methylated arginines, and L-arginine (measured using LC-MS/MS) were collected from a population-based sample of older Australian adults from the Hunter Community Study. The five key lung function measures included as outcomes were Forced Expiratory Volume in 1 second, Forced Vital Capacity, Forced Expiratory Volume in 1 second to Forced Vital Capacity ratio, Percent Predicted Forced Expiratory Volume in 1 second, and Percent Predicted Forced Vital Capacity.MEASUREMENTS AND MAIN RESULTS: In adjusted analyses there were statistically significant independent associations between a) higher asymmetric dimethylarginine, lower Forced Expiratory Volume in 1 second and lower Forced Vital Capacity; and b) lower L-arginine/asymmetric dimethylarginine ratio, lower Forced Expiratory Volume in 1 second, lower Percent Predicted Forced Expiratory Volume in 1 second and lower Percent Predicted Forced Vital Capacity. By contrast, no significant associations were observed between symmetric dimethylarginine and lung function.CONCLUSIONS: After adjusting for clinical, demographic, biochemical, and pharmacological confounders, higher serum asymmetric dimethylarginine was independently associated with a reduction in key measures of lung function. Further research is needed to determine if methylarginines predict the decline in lung function.

AB - RATIONALE: Methylarginines are endogenous nitric oxide synthase inhibitors that have been implicated in animal models of lung disease but have not previously been examined for their association with spirometric measures of lung function in humans.OBJECTIVES: This study measured serum concentrations of asymmetric and symmetric dimethylarginine in a representative sample of older community-dwelling adults and determined their association with spirometric lung function measures.METHODS: Data on clinical, lifestyle, and demographic characteristics, methylated arginines, and L-arginine (measured using LC-MS/MS) were collected from a population-based sample of older Australian adults from the Hunter Community Study. The five key lung function measures included as outcomes were Forced Expiratory Volume in 1 second, Forced Vital Capacity, Forced Expiratory Volume in 1 second to Forced Vital Capacity ratio, Percent Predicted Forced Expiratory Volume in 1 second, and Percent Predicted Forced Vital Capacity.MEASUREMENTS AND MAIN RESULTS: In adjusted analyses there were statistically significant independent associations between a) higher asymmetric dimethylarginine, lower Forced Expiratory Volume in 1 second and lower Forced Vital Capacity; and b) lower L-arginine/asymmetric dimethylarginine ratio, lower Forced Expiratory Volume in 1 second, lower Percent Predicted Forced Expiratory Volume in 1 second and lower Percent Predicted Forced Vital Capacity. By contrast, no significant associations were observed between symmetric dimethylarginine and lung function.CONCLUSIONS: After adjusting for clinical, demographic, biochemical, and pharmacological confounders, higher serum asymmetric dimethylarginine was independently associated with a reduction in key measures of lung function. Further research is needed to determine if methylarginines predict the decline in lung function.

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