Setting research priorities to improve global newborn health and prevent stillbirths by 2025

Sachiyo Yoshida, José Martines, Joy E. Lawn, Stephen Wall, Joăo Paulo Souza, Igor Rudan, Simon Cousens, Peter Aaby, Ishag Adam, Ramesh Kant Adhikari, Namasivayam Ambalavanan, Shams El Arifeen, Dhana Raj Aryal, Sk Asiruddin, Abdullah Baqui, Aluisio J. D. Barros, Christine S. Benn, Vineet Bhandari, Shinjini Bhatnagar, Sohinee BhattacharyaZulfiqar A. Bhutta, Robert E. Black, Hannah Blencowe, Carl Bose, Justin Brown, Christoph Bührer, Wally Carlo, Jose Guilherme Cecatti, Po-Yin Cheung, Robert Clark, Tim Colbourn, Agustin Conde-Agudelo, Erica Corbett, Andrew E. Czeizel, Abhik Das, Louise Tina Day, Carolyn Deal, Ashok Deorari, Uğur Dilmen, Mike English, Cyril Engmann, Fabian Esamai, Caroline Fall, Donna M. Ferriero, Peter Gisore, Tabish Hazir, Rosemary D. Higgins, Caroline S. E. Homer, D. E. Hoque, Lorentz Irgens, neonatal health research priority setting group

Research output: Contribution to journalArticle

38 Citations (Scopus)
4 Downloads (Pure)

Abstract

BACKGROUND: In 2013, an estimated 2.8 million newborns died and 2.7 million were stillborn. A much greater number suffer from long term impairment associated with preterm birth, intrauterine growth restriction, congenital anomalies, and perinatal or infectious causes. With the approaching deadline for the achievement of the Millennium Development Goals (MDGs) in 2015, there was a need to set the new research priorities on newborns and stillbirth with a focus not only on survival but also on health, growth and development. We therefore carried out a systematic exercise to set newborn health research priorities for 2013-2025.

METHODS: We used adapted Child Health and Nutrition Research Initiative (CHNRI) methods for this prioritization exercise. We identified and approached the 200 most productive researchers and 400 program experts, and 132 of them submitted research questions online. These were collated into a set of 205 research questions, sent for scoring to the 600 identified experts, and were assessed and scored by 91 experts.

RESULTS: Nine out of top ten identified priorities were in the domain of research on improving delivery of known interventions, with simplified neonatal resuscitation program and clinical algorithms and improved skills of community health workers leading the list. The top 10 priorities in the domain of development were led by ideas on improved Kangaroo Mother Care at community level, how to improve the accuracy of diagnosis by community health workers, and perinatal audits. The 10 leading priorities for discovery research focused on stable surfactant with novel modes of administration for preterm babies, ability to diagnose fetal distress and novel tocolytic agents to delay or stop preterm labour.

CONCLUSION: These findings will assist both donors and researchers in supporting and conducting research to close the knowledge gaps for reducing neonatal mortality, morbidity and long term impairment. WHO, SNL and other partners will work to generate interest among key national stakeholders, governments, NGOs, and research institutes in these priorities, while encouraging research funders to support them. We will track research funding, relevant requests for proposals and trial registers to monitor if the priorities identified by this exercise are being addressed.

Original languageEnglish
Article number010508
Pages (from-to)1-10
Number of pages10
JournalJournal of Global Health
Volume6
Issue number1
Publication statusPublished - Jun 2016

Fingerprint

Stillbirth
Research
Exercise
Kangaroo-Mother Care Method
Competitive Bidding
Research Personnel
Global Health
Infant Health
Newborn Infant
Tocolytic Agents
Health Priorities
Fetal Distress
Federal Government
Aptitude
Premature Obstetric Labor
Premature Birth
Infant Mortality
Growth and Development
Surface-Active Agents
Resuscitation

Cite this

Yoshida, S., Martines, J., Lawn, J. E., Wall, S., Souza, J. P., Rudan, I., ... neonatal health research priority setting group (2016). Setting research priorities to improve global newborn health and prevent stillbirths by 2025. Journal of Global Health, 6(1), 1-10. [010508].

Setting research priorities to improve global newborn health and prevent stillbirths by 2025. / Yoshida, Sachiyo; Martines, José; Lawn, Joy E.; Wall, Stephen; Souza, Joăo Paulo; Rudan, Igor; Cousens, Simon; Aaby, Peter; Adam, Ishag; Adhikari, Ramesh Kant; Ambalavanan, Namasivayam; Arifeen, Shams El; Aryal, Dhana Raj; Asiruddin, Sk; Baqui, Abdullah; Barros, Aluisio J. D.; Benn, Christine S.; Bhandari, Vineet; Bhatnagar, Shinjini; Bhattacharya, Sohinee; Bhutta, Zulfiqar A.; Black, Robert E.; Blencowe, Hannah; Bose, Carl; Brown, Justin; Bührer, Christoph; Carlo, Wally; Cecatti, Jose Guilherme; Cheung, Po-Yin; Clark, Robert; Colbourn, Tim; Conde-Agudelo, Agustin; Corbett, Erica; Czeizel, Andrew E.; Das, Abhik; Day, Louise Tina; Deal, Carolyn; Deorari, Ashok; Dilmen, Uğur; English, Mike; Engmann, Cyril; Esamai, Fabian; Fall, Caroline; Ferriero, Donna M.; Gisore, Peter; Hazir, Tabish; Higgins, Rosemary D.; Homer, Caroline S. E.; Hoque, D. E.; Irgens, Lorentz; neonatal health research priority setting group.

In: Journal of Global Health, Vol. 6, No. 1, 010508, 06.2016, p. 1-10.

Research output: Contribution to journalArticle

Yoshida, S, Martines, J, Lawn, JE, Wall, S, Souza, JP, Rudan, I, Cousens, S, Aaby, P, Adam, I, Adhikari, RK, Ambalavanan, N, Arifeen, SE, Aryal, DR, Asiruddin, S, Baqui, A, Barros, AJD, Benn, CS, Bhandari, V, Bhatnagar, S, Bhattacharya, S, Bhutta, ZA, Black, RE, Blencowe, H, Bose, C, Brown, J, Bührer, C, Carlo, W, Cecatti, JG, Cheung, P-Y, Clark, R, Colbourn, T, Conde-Agudelo, A, Corbett, E, Czeizel, AE, Das, A, Day, LT, Deal, C, Deorari, A, Dilmen, U, English, M, Engmann, C, Esamai, F, Fall, C, Ferriero, DM, Gisore, P, Hazir, T, Higgins, RD, Homer, CSE, Hoque, DE, Irgens, L & neonatal health research priority setting group 2016, 'Setting research priorities to improve global newborn health and prevent stillbirths by 2025', Journal of Global Health, vol. 6, no. 1, 010508, pp. 1-10.
Yoshida S, Martines J, Lawn JE, Wall S, Souza JP, Rudan I et al. Setting research priorities to improve global newborn health and prevent stillbirths by 2025. Journal of Global Health. 2016 Jun;6(1):1-10. 010508.
Yoshida, Sachiyo ; Martines, José ; Lawn, Joy E. ; Wall, Stephen ; Souza, Joăo Paulo ; Rudan, Igor ; Cousens, Simon ; Aaby, Peter ; Adam, Ishag ; Adhikari, Ramesh Kant ; Ambalavanan, Namasivayam ; Arifeen, Shams El ; Aryal, Dhana Raj ; Asiruddin, Sk ; Baqui, Abdullah ; Barros, Aluisio J. D. ; Benn, Christine S. ; Bhandari, Vineet ; Bhatnagar, Shinjini ; Bhattacharya, Sohinee ; Bhutta, Zulfiqar A. ; Black, Robert E. ; Blencowe, Hannah ; Bose, Carl ; Brown, Justin ; Bührer, Christoph ; Carlo, Wally ; Cecatti, Jose Guilherme ; Cheung, Po-Yin ; Clark, Robert ; Colbourn, Tim ; Conde-Agudelo, Agustin ; Corbett, Erica ; Czeizel, Andrew E. ; Das, Abhik ; Day, Louise Tina ; Deal, Carolyn ; Deorari, Ashok ; Dilmen, Uğur ; English, Mike ; Engmann, Cyril ; Esamai, Fabian ; Fall, Caroline ; Ferriero, Donna M. ; Gisore, Peter ; Hazir, Tabish ; Higgins, Rosemary D. ; Homer, Caroline S. E. ; Hoque, D. E. ; Irgens, Lorentz ; neonatal health research priority setting group. / Setting research priorities to improve global newborn health and prevent stillbirths by 2025. In: Journal of Global Health. 2016 ; Vol. 6, No. 1. pp. 1-10.
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abstract = "BACKGROUND: In 2013, an estimated 2.8 million newborns died and 2.7 million were stillborn. A much greater number suffer from long term impairment associated with preterm birth, intrauterine growth restriction, congenital anomalies, and perinatal or infectious causes. With the approaching deadline for the achievement of the Millennium Development Goals (MDGs) in 2015, there was a need to set the new research priorities on newborns and stillbirth with a focus not only on survival but also on health, growth and development. We therefore carried out a systematic exercise to set newborn health research priorities for 2013-2025.METHODS: We used adapted Child Health and Nutrition Research Initiative (CHNRI) methods for this prioritization exercise. We identified and approached the 200 most productive researchers and 400 program experts, and 132 of them submitted research questions online. These were collated into a set of 205 research questions, sent for scoring to the 600 identified experts, and were assessed and scored by 91 experts.RESULTS: Nine out of top ten identified priorities were in the domain of research on improving delivery of known interventions, with simplified neonatal resuscitation program and clinical algorithms and improved skills of community health workers leading the list. The top 10 priorities in the domain of development were led by ideas on improved Kangaroo Mother Care at community level, how to improve the accuracy of diagnosis by community health workers, and perinatal audits. The 10 leading priorities for discovery research focused on stable surfactant with novel modes of administration for preterm babies, ability to diagnose fetal distress and novel tocolytic agents to delay or stop preterm labour.CONCLUSION: These findings will assist both donors and researchers in supporting and conducting research to close the knowledge gaps for reducing neonatal mortality, morbidity and long term impairment. WHO, SNL and other partners will work to generate interest among key national stakeholders, governments, NGOs, and research institutes in these priorities, while encouraging research funders to support them. We will track research funding, relevant requests for proposals and trial registers to monitor if the priorities identified by this exercise are being addressed.",
author = "Sachiyo Yoshida and Jos{\'e} Martines and Lawn, {Joy E.} and Stephen Wall and Souza, {Joăo Paulo} and Igor Rudan and Simon Cousens and Peter Aaby and Ishag Adam and Adhikari, {Ramesh Kant} and Namasivayam Ambalavanan and Arifeen, {Shams El} and Aryal, {Dhana Raj} and Sk Asiruddin and Abdullah Baqui and Barros, {Aluisio J. D.} and Benn, {Christine S.} and Vineet Bhandari and Shinjini Bhatnagar and Sohinee Bhattacharya and Bhutta, {Zulfiqar A.} and Black, {Robert E.} and Hannah Blencowe and Carl Bose and Justin Brown and Christoph B{\"u}hrer and Wally Carlo and Cecatti, {Jose Guilherme} and Po-Yin Cheung and Robert Clark and Tim Colbourn and Agustin Conde-Agudelo and Erica Corbett and Czeizel, {Andrew E.} and Abhik Das and Day, {Louise Tina} and Carolyn Deal and Ashok Deorari and Uğur Dilmen and Mike English and Cyril Engmann and Fabian Esamai and Caroline Fall and Ferriero, {Donna M.} and Peter Gisore and Tabish Hazir and Higgins, {Rosemary D.} and Homer, {Caroline S. E.} and Hoque, {D. E.} and Lorentz Irgens and {neonatal health research priority setting group}",
note = "Acknowledgements: The authors thank the expert group for their time and effort in this priority–setting exercise, and the contribution of anonymous reviewers to the final version of this report. We acknowledge inputs from Dr Diane Morof from Centers for Disease Control and Prevention, USA. Funding: This work was supported by Save the Children.",
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T1 - Setting research priorities to improve global newborn health and prevent stillbirths by 2025

AU - Yoshida, Sachiyo

AU - Martines, José

AU - Lawn, Joy E.

AU - Wall, Stephen

AU - Souza, Joăo Paulo

AU - Rudan, Igor

AU - Cousens, Simon

AU - Aaby, Peter

AU - Adam, Ishag

AU - Adhikari, Ramesh Kant

AU - Ambalavanan, Namasivayam

AU - Arifeen, Shams El

AU - Aryal, Dhana Raj

AU - Asiruddin, Sk

AU - Baqui, Abdullah

AU - Barros, Aluisio J. D.

AU - Benn, Christine S.

AU - Bhandari, Vineet

AU - Bhatnagar, Shinjini

AU - Bhattacharya, Sohinee

AU - Bhutta, Zulfiqar A.

AU - Black, Robert E.

AU - Blencowe, Hannah

AU - Bose, Carl

AU - Brown, Justin

AU - Bührer, Christoph

AU - Carlo, Wally

AU - Cecatti, Jose Guilherme

AU - Cheung, Po-Yin

AU - Clark, Robert

AU - Colbourn, Tim

AU - Conde-Agudelo, Agustin

AU - Corbett, Erica

AU - Czeizel, Andrew E.

AU - Das, Abhik

AU - Day, Louise Tina

AU - Deal, Carolyn

AU - Deorari, Ashok

AU - Dilmen, Uğur

AU - English, Mike

AU - Engmann, Cyril

AU - Esamai, Fabian

AU - Fall, Caroline

AU - Ferriero, Donna M.

AU - Gisore, Peter

AU - Hazir, Tabish

AU - Higgins, Rosemary D.

AU - Homer, Caroline S. E.

AU - Hoque, D. E.

AU - Irgens, Lorentz

AU - neonatal health research priority setting group

N1 - Acknowledgements: The authors thank the expert group for their time and effort in this priority–setting exercise, and the contribution of anonymous reviewers to the final version of this report. We acknowledge inputs from Dr Diane Morof from Centers for Disease Control and Prevention, USA. Funding: This work was supported by Save the Children.

PY - 2016/6

Y1 - 2016/6

N2 - BACKGROUND: In 2013, an estimated 2.8 million newborns died and 2.7 million were stillborn. A much greater number suffer from long term impairment associated with preterm birth, intrauterine growth restriction, congenital anomalies, and perinatal or infectious causes. With the approaching deadline for the achievement of the Millennium Development Goals (MDGs) in 2015, there was a need to set the new research priorities on newborns and stillbirth with a focus not only on survival but also on health, growth and development. We therefore carried out a systematic exercise to set newborn health research priorities for 2013-2025.METHODS: We used adapted Child Health and Nutrition Research Initiative (CHNRI) methods for this prioritization exercise. We identified and approached the 200 most productive researchers and 400 program experts, and 132 of them submitted research questions online. These were collated into a set of 205 research questions, sent for scoring to the 600 identified experts, and were assessed and scored by 91 experts.RESULTS: Nine out of top ten identified priorities were in the domain of research on improving delivery of known interventions, with simplified neonatal resuscitation program and clinical algorithms and improved skills of community health workers leading the list. The top 10 priorities in the domain of development were led by ideas on improved Kangaroo Mother Care at community level, how to improve the accuracy of diagnosis by community health workers, and perinatal audits. The 10 leading priorities for discovery research focused on stable surfactant with novel modes of administration for preterm babies, ability to diagnose fetal distress and novel tocolytic agents to delay or stop preterm labour.CONCLUSION: These findings will assist both donors and researchers in supporting and conducting research to close the knowledge gaps for reducing neonatal mortality, morbidity and long term impairment. WHO, SNL and other partners will work to generate interest among key national stakeholders, governments, NGOs, and research institutes in these priorities, while encouraging research funders to support them. We will track research funding, relevant requests for proposals and trial registers to monitor if the priorities identified by this exercise are being addressed.

AB - BACKGROUND: In 2013, an estimated 2.8 million newborns died and 2.7 million were stillborn. A much greater number suffer from long term impairment associated with preterm birth, intrauterine growth restriction, congenital anomalies, and perinatal or infectious causes. With the approaching deadline for the achievement of the Millennium Development Goals (MDGs) in 2015, there was a need to set the new research priorities on newborns and stillbirth with a focus not only on survival but also on health, growth and development. We therefore carried out a systematic exercise to set newborn health research priorities for 2013-2025.METHODS: We used adapted Child Health and Nutrition Research Initiative (CHNRI) methods for this prioritization exercise. We identified and approached the 200 most productive researchers and 400 program experts, and 132 of them submitted research questions online. These were collated into a set of 205 research questions, sent for scoring to the 600 identified experts, and were assessed and scored by 91 experts.RESULTS: Nine out of top ten identified priorities were in the domain of research on improving delivery of known interventions, with simplified neonatal resuscitation program and clinical algorithms and improved skills of community health workers leading the list. The top 10 priorities in the domain of development were led by ideas on improved Kangaroo Mother Care at community level, how to improve the accuracy of diagnosis by community health workers, and perinatal audits. The 10 leading priorities for discovery research focused on stable surfactant with novel modes of administration for preterm babies, ability to diagnose fetal distress and novel tocolytic agents to delay or stop preterm labour.CONCLUSION: These findings will assist both donors and researchers in supporting and conducting research to close the knowledge gaps for reducing neonatal mortality, morbidity and long term impairment. WHO, SNL and other partners will work to generate interest among key national stakeholders, governments, NGOs, and research institutes in these priorities, while encouraging research funders to support them. We will track research funding, relevant requests for proposals and trial registers to monitor if the priorities identified by this exercise are being addressed.

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JO - Journal of Global Health

JF - Journal of Global Health

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