Setting research priorities to improve global newborn health and prevent stillbirths by 2025

Sachiyo Yoshida, José Martines, Joy E. Lawn, Stephen Wall, Joăo Paulo Souza, Igor Rudan, Simon Cousens, Peter Aaby, Ishag Adam, Ramesh Kant Adhikari, Namasivayam Ambalavanan, Shams El Arifeen, Dhana Raj Aryal, Sk Asiruddin, Abdullah Baqui, Aluisio J. D. Barros, Christine S. Benn, Vineet Bhandari, Shinjini Bhatnagar, Sohinee BhattacharyaZulfiqar A. Bhutta, Robert E. Black, Hannah Blencowe, Carl Bose, Justin Brown, Christoph Bührer, Wally Carlo, Jose Guilherme Cecatti, Po-Yin Cheung, Robert Clark, Tim Colbourn, Agustin Conde-Agudelo, Erica Corbett, Andrew E. Czeizel, Abhik Das, Louise Tina Day, Carolyn Deal, Ashok Deorari, Uğur Dilmen, Mike English, Cyril Engmann, Fabian Esamai, Caroline Fall, Donna M. Ferriero, Peter Gisore, Tabish Hazir, Rosemary D. Higgins, Caroline S. E. Homer, D. E. Hoque, Lorentz Irgens, neonatal health research priority setting group

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Abstract

BACKGROUND: In 2013, an estimated 2.8 million newborns died and 2.7 million were stillborn. A much greater number suffer from long term impairment associated with preterm birth, intrauterine growth restriction, congenital anomalies, and perinatal or infectious causes. With the approaching deadline for the achievement of the Millennium Development Goals (MDGs) in 2015, there was a need to set the new research priorities on newborns and stillbirth with a focus not only on survival but also on health, growth and development. We therefore carried out a systematic exercise to set newborn health research priorities for 2013-2025.

METHODS: We used adapted Child Health and Nutrition Research Initiative (CHNRI) methods for this prioritization exercise. We identified and approached the 200 most productive researchers and 400 program experts, and 132 of them submitted research questions online. These were collated into a set of 205 research questions, sent for scoring to the 600 identified experts, and were assessed and scored by 91 experts.

RESULTS: Nine out of top ten identified priorities were in the domain of research on improving delivery of known interventions, with simplified neonatal resuscitation program and clinical algorithms and improved skills of community health workers leading the list. The top 10 priorities in the domain of development were led by ideas on improved Kangaroo Mother Care at community level, how to improve the accuracy of diagnosis by community health workers, and perinatal audits. The 10 leading priorities for discovery research focused on stable surfactant with novel modes of administration for preterm babies, ability to diagnose fetal distress and novel tocolytic agents to delay or stop preterm labour.

CONCLUSION: These findings will assist both donors and researchers in supporting and conducting research to close the knowledge gaps for reducing neonatal mortality, morbidity and long term impairment. WHO, SNL and other partners will work to generate interest among key national stakeholders, governments, NGOs, and research institutes in these priorities, while encouraging research funders to support them. We will track research funding, relevant requests for proposals and trial registers to monitor if the priorities identified by this exercise are being addressed.

Original languageEnglish
Article number010508
Pages (from-to)1-10
Number of pages10
JournalJournal of Global Health
Volume6
Issue number1
DOIs
Publication statusPublished - 30 Jun 2016

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    Yoshida, S., Martines, J., Lawn, J. E., Wall, S., Souza, J. P., Rudan, I., Cousens, S., Aaby, P., Adam, I., Adhikari, R. K., Ambalavanan, N., Arifeen, S. E., Aryal, D. R., Asiruddin, S., Baqui, A., Barros, A. J. D., Benn, C. S., Bhandari, V., Bhatnagar, S., ... neonatal health research priority setting group (2016). Setting research priorities to improve global newborn health and prevent stillbirths by 2025. Journal of Global Health, 6(1), 1-10. [010508]. https://doi.org/10.7189/jogh.06.010508