Severe intravascular haemolysis in a renal transplant recipient due to anti-B of donor origin

J Orchard, Neil Thomas Young, C Smith, S Thomas, C Darke

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11 Citations (Scopus)

Abstract

A group B recipient of a group 0 kidney developed severe intravascular haemolysis due to the formation of anti-B. Immunoglobulin allotyping of donor serum, recipient serum and 'unexpected' anti-B antibody showed the antibody to be of donor origin. The patient and donor genotypes were Gm 3;5/3;5 and Gm 1,2;21/1;21, respectively, and the anti-B antibody allotype was Gm 1;21. The group B recipient of the other donor kidney showed no evidence of haemolysis. Possible factors influencing the occurrence and severity of post-transplantation haemolysis are discussed. The production of anti-A or anti-B antibodies in non-group 0 patients who receive group 0 organ transplants is well described [1-8]. We report a case of severe intravascular haemolysis in a group B patient who received a group 0 kidney, together with immunoglobulin allotyping studies which show conclusively that the antibody responsible for the haemolysis was of donor origin.
Original languageEnglish
Pages (from-to)172-175
Number of pages4
JournalVox Sanguinis
Volume59
Issue number3
DOIs
Publication statusPublished - 1 Jan 1990

Keywords

  • ABO Blood-Group System
  • Antibodies
  • Blood Transfusion
  • Coombs' Test
  • Hemolysis
  • Humans
  • Kidney Transplantation
  • Male
  • Middle Aged

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