Abstract
A group B recipient of a group 0 kidney developed severe intravascular haemolysis due to the formation of anti-B. Immunoglobulin allotyping of donor serum, recipient serum and 'unexpected' anti-B antibody showed the antibody to be of donor origin. The patient and donor genotypes were Gm 3;5/3;5 and Gm 1,2;21/1;21, respectively, and the anti-B antibody allotype was Gm 1;21. The group B recipient of the other donor kidney showed no evidence of haemolysis. Possible factors influencing the occurrence and severity of post-transplantation haemolysis are discussed. The production of anti-A or anti-B antibodies in non-group 0 patients who receive group 0 organ transplants is well described [1-8]. We report a case of severe intravascular haemolysis in a group B patient who received a group 0 kidney, together with immunoglobulin allotyping studies which show conclusively that the antibody responsible for the haemolysis was of donor origin.
Original language | English |
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Pages (from-to) | 172-175 |
Number of pages | 4 |
Journal | Vox Sanguinis |
Volume | 59 |
Issue number | 3 |
DOIs | |
Publication status | Published - 1 Jan 1990 |
Keywords
- ABO Blood-Group System
- Antibodies
- Blood Transfusion
- Coombs' Test
- Hemolysis
- Humans
- Kidney Transplantation
- Male
- Middle Aged