Sex-differences in grey-white matter structure in normal-reading and dyslexic adolescents

Anca-Larisa Sandu-Giuraniuc (Corresponding Author), Karsten Specht, Harald Beneventi , Arvid Lundervold, Kenneth Hugdahl

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

MR images were used to look for brain structure irregularities in adolescent children with dyslexia by use of combined grey and white matter volume measurements and fractal dimension (FD) of the grey–white matter border. The data were collected from 13 dyslexic adolescent (8 boys and 5 girls) that were compared with 18 control subjects (8 boys and 10 girls). The MR images were first segmented, and the volume as well as the FD of the grey/white matter border for the whole brain and for each hemisphere was computed. Changes were found in the measured volumes of both grey and white matter and were best reflected in the ratio of grey/white matter and in FD values, especially in the left hemisphere. The results showed that, although dyslexia is less frequent in women, the structural differences in the brain are more pronounced in their case, pointing to an increased vulnerability of the female brain to morphological changes associated with dyslexia.
Original languageEnglish
Pages (from-to)80-84
Number of pages5
JournalNeuroscience Letters
Volume438
Issue number1
Early online date11 Apr 2008
DOIs
Publication statusPublished - 13 Jun 2008

Keywords

  • Dyslexia
  • Gray matter/white matter ratio
  • Fractal dimension
  • Sex-differences
  • Morphometry

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