Abstract
Background: Systemic lupus erythematosus (SLE) is an autoimmune disorder associated with increased stroke risk. Its association with stroke outcomes remains poorly understood. In this study, we aimed to compare the sex-specific SLE-associated acute stroke outcomes. Methods: Stroke hospitalisations between 2015 and 2018 from the National Inpatient Sample were analysed. The associations between SLE and outcomes (inpatient mortality, length-of-stay > 4 days and routine discharge) were examined using multivariable logistic regressions, stratifying by sex and adjusting for age, race, stroke type, revascularisation, hospital characteristics and comorbidities. Results: A total of 316,531 records representing 1,581,430 hospitalisations were included. Median (interquartile range) age was 71 (60–82) years. There were 940 (0.06%) males and 6110 (0.39%) females with SLE. There were no associations between SLE and mortality amongst either females (odds ratio (95% confidence interval) = 1.11 (0.84–1.48)) or males (0.81 (0.34–1.94)). Nevertheless, SLE was associated with prolonged hospitalisation (1.17 (1.03–1.32)) and lower odds of routine discharge (0.82 (0.72–0.94)) amongst females. There were no associations between SLE and other adverse outcomes amongst males. Conclusions: The association between SLE and acute stroke outcomes was influenced by sex. While SLE was not associated with mortality in either sex, females with SLE had higher odds of prolonged hospitalisation and lower odds of routine home discharge compared to patients without SLE, while males did not exhibit this increased risk.
Original language | English |
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Article number | 462 |
Number of pages | 14 |
Journal | Journal of Clinical Medicine |
Volume | 12 |
Issue number | 2 |
Early online date | 6 Jan 2023 |
DOIs | |
Publication status | Published - 2023 |
Bibliographical note
We would like to acknowledge the HCUP Data Partners (https://www.hcup-us.ahrq.gov/db/hcupdatapartners.jsp, accessed on 28 December 2022).Data Availability Statement
The data supporting the findings of this study are available from the corresponding author upon reasonable request.Keywords
- stroke
- Systemic lupus erythematosus
- sex differences