Abstract
PURPOSE: The purpose of this study was to show the viability and performance of a shape-based pattern recognition technique applied to I-N-omega-fluoropropyl-2-beta-carbomethoxy-3beta-(4-iodophenyl) nortropane single-photon emission computed tomography (FP-CIT SPECT) in patients with parkinsonism. METHODS: A fully automated pattern recognition tool, based on the shape of FP-CIT SPECT images, was written using Java. Its performance was evaluated and compared with QuantiSPECT, a region-of-interest-based quantitation tool, and observer performance using receiver operating characteristic analysis and kappa statistics. The techniques were compared using a sample of patients and controls recruited from a prospective community-based study of first presentation of parkinsonian symptoms with longitudinal follow up (median 3 years). RESULTS: The shape-based technique as well as the conventional semiquantitative approach was performed by experienced observers. The technique had a high level of automation, thereby avoiding observer/operator variability. CONCLUSION: A pattern recognition approach is a viable alternative to traditional methods of analysis in FP-CIT SPECT and has additional advantages.
Original language | English |
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Pages (from-to) | 194-201 |
Number of pages | 8 |
Journal | Nuclear Medicine Communications |
Volume | 30 |
Issue number | 3 |
DOIs | |
Publication status | Published - Mar 2009 |
Keywords
- case-control studies
- female
- follow-up studies
- humans
- male
- neostriatum
- Parkinsonian disorders
- reproducibility of results
- tomography, emission-computed, single-photon
- tropanes
- 123I-N-[omega]-fluoropropyl-2-[beta]-carbomethoxy-3[beta]-(4-iodophenyl) nortropane
- neurodegenerative diseases
- Parkinson's disease
- pattern recognition
- single-photon emission computed tomography
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Parkinsonism Incidence in North East Scotland (PINE) study database
Counsell, C. (Owner), Wilde, K. (Creator) & Ritchie, D. M. (Data Manager), University of Aberdeen, 1 Apr 2009
Dataset