Abstract
DNA is replicated according to a precise and reproducible temporal pattern. The S-phase programme has previously been analyzed in metazoan and yeast cells using different methods: cytological chromosome banding in human cells and DNA isotopic-labeling techniques in yeast. Microarray-based approaches for the analysis of the replication programme and chromatin structure are bringing us closer to a molecular understanding of the factors that determine replication time. In this article, I assess the impact of recent investigations and compare our knowledge of DNA replication-timing controls in yeast with those of metazoans.
| Original language | English |
|---|---|
| Pages (from-to) | 444-449 |
| Number of pages | 6 |
| Journal | Trends in Genetics |
| Volume | 21 |
| DOIs | |
| Publication status | Published - 2005 |
Keywords
- S-PHASE
- HIGH-RESOLUTION
- HUMAN GENOME
- CHROMOSOME
- TRANSCRIPTION
- YEAST
- HETEROCHROMATIN
- COORDINATION
- ORIGINS
- PROFILE