Shaping time: chromatin structure and the DNA replication programme

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Abstract

DNA is replicated according to a precise and reproducible temporal pattern. The S-phase programme has previously been analyzed in metazoan and yeast cells using different methods: cytological chromosome banding in human cells and DNA isotopic-labeling techniques in yeast. Microarray-based approaches for the analysis of the replication programme and chromatin structure are bringing us closer to a molecular understanding of the factors that determine replication time. In this article, I assess the impact of recent investigations and compare our knowledge of DNA replication-timing controls in yeast with those of metazoans.

Original languageEnglish
Pages (from-to)444-449
Number of pages6
JournalTrends in Genetics
Volume21
DOIs
Publication statusPublished - 2005

Keywords

  • S-PHASE
  • HIGH-RESOLUTION
  • HUMAN GENOME
  • CHROMOSOME
  • TRANSCRIPTION
  • YEAST
  • HETEROCHROMATIN
  • COORDINATION
  • ORIGINS
  • PROFILE

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