Should non-mosaic Klinefelter syndrome men be labelled as infertile in 2009?

G Fullerton, M Hamilton, A Maheshwari

Research output: Contribution to journalArticle

92 Citations (Scopus)

Abstract

BACKGROUND Klinefelter syndrome is a common genetic condition. Affected non-mosaic men are azoospermic and have been labelled as infertile. Despite reports that these men can have children using assisted reproduction techniques, it is not common practice in the UK to offer sperm retrieval to these men.
METHODS Medline and EMBASE (1980–2009) were searched independently by two authors and all studies involving surgical sperm retrieval in non-mosaic Klinefelter syndrome were included. The primary outcome was success of surgical sperm retrieval and the secondary outcome was live birth rate.
RESULTS The overall success rate for sperm retrieval was 44%, with a higher rate of success using micro-dissection testicular sperm aspiration (micro-TESE) (55%). This, along with ICSI, has led to the birth of 101 children. However, there are no known predictors for successful sperm retrieval. Although there are concerns about genetic risk to the offspring of non-mosaic Klinefelter patients, this risk has not been found to be greater than that of patients with non-obstructive azoospermia with normal karyotype.
CONCLUSIONS It is possible for a man with non-mosaic Klinefelter to father a child. However, before these techniques are offered, some ethical issues need to be explored.
Original languageEnglish
Pages (from-to)588-597
Number of pages10
JournalHuman Reproduction
Volume25
Issue number3
Early online date19 Jan 2010
DOIs
Publication statusPublished - Mar 2010

Fingerprint

Sperm Retrieval
Klinefelter Syndrome
Reproductive Techniques
Azoospermia
Intracytoplasmic Sperm Injections
Birth Rate
Live Birth
Karyotype
Ethics
Fathers
Dissection
Parturition

Keywords

  • adult
  • age factors
  • aneuploidy
  • azoospermia
  • congenital abnormalities
  • female
  • humans
  • infertility, male
  • Klinefelter Syndrome
  • male
  • mosaicism
  • pregnancy
  • pregnancy outcome
  • preimplantation diagnosis
  • risk
  • sperm injections, intracytoplasmic
  • sperm retrieval

Cite this

Should non-mosaic Klinefelter syndrome men be labelled as infertile in 2009? / Fullerton, G; Hamilton, M; Maheshwari, A.

In: Human Reproduction, Vol. 25, No. 3, 03.2010, p. 588-597.

Research output: Contribution to journalArticle

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abstract = "BACKGROUND Klinefelter syndrome is a common genetic condition. Affected non-mosaic men are azoospermic and have been labelled as infertile. Despite reports that these men can have children using assisted reproduction techniques, it is not common practice in the UK to offer sperm retrieval to these men. METHODS Medline and EMBASE (1980–2009) were searched independently by two authors and all studies involving surgical sperm retrieval in non-mosaic Klinefelter syndrome were included. The primary outcome was success of surgical sperm retrieval and the secondary outcome was live birth rate. RESULTS The overall success rate for sperm retrieval was 44{\%}, with a higher rate of success using micro-dissection testicular sperm aspiration (micro-TESE) (55{\%}). This, along with ICSI, has led to the birth of 101 children. However, there are no known predictors for successful sperm retrieval. Although there are concerns about genetic risk to the offspring of non-mosaic Klinefelter patients, this risk has not been found to be greater than that of patients with non-obstructive azoospermia with normal karyotype. CONCLUSIONS It is possible for a man with non-mosaic Klinefelter to father a child. However, before these techniques are offered, some ethical issues need to be explored.",
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AB - BACKGROUND Klinefelter syndrome is a common genetic condition. Affected non-mosaic men are azoospermic and have been labelled as infertile. Despite reports that these men can have children using assisted reproduction techniques, it is not common practice in the UK to offer sperm retrieval to these men. METHODS Medline and EMBASE (1980–2009) were searched independently by two authors and all studies involving surgical sperm retrieval in non-mosaic Klinefelter syndrome were included. The primary outcome was success of surgical sperm retrieval and the secondary outcome was live birth rate. RESULTS The overall success rate for sperm retrieval was 44%, with a higher rate of success using micro-dissection testicular sperm aspiration (micro-TESE) (55%). This, along with ICSI, has led to the birth of 101 children. However, there are no known predictors for successful sperm retrieval. Although there are concerns about genetic risk to the offspring of non-mosaic Klinefelter patients, this risk has not been found to be greater than that of patients with non-obstructive azoospermia with normal karyotype. CONCLUSIONS It is possible for a man with non-mosaic Klinefelter to father a child. However, before these techniques are offered, some ethical issues need to be explored.

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