Signalling C-Type lectin receptors, microbial recognition and immunity

J. Claire Hoving; Gillian J.  Watson; Gordon D Brown

doi:10.1111/cmi.12249

Signalling C-Type lectin receptors, microbial recognition and immunity

J. Claire Hoving, Gillian J. Watson, Gordon D Brown

Applied Medicine

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196 Citations (Scopus)

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Abstract

Signalling C-type lectin receptors (CLRs) are crucial in shaping the immune response to fungal pathogens, but comparably little is known about the role of these receptors in bacterial, viral and parasitic infections. CLRs have many diverse functions depending on the signalling motifs in their cytoplasmic domains, and can induce endocytic, phagocytic, antimicrobial, pro-inflammatory or anti-inflammatory responses which are either protective or not during an infection. Understanding the role of CLRs in shaping anti-microbial immunity offers great potential for the future development of therapeutics for disease intervention. In this review we will focus on the recognition of bacterial, viral and parasitic pathogens by CLRs, and how these receptors influence the outcome of infection. We will also provide a brief update on the role of CLRs in antifungal immunity.

Original language	English
Pages (from-to)	185-194
Number of pages	10
Journal	Cellular Microbiology
Volume	16
Issue number	2
Early online date	10 Jan 2014
DOIs	https://doi.org/10.1111/cmi.12249
Publication status	Published - Feb 2014

Bibliographical note

This work was supported in part by the Wellcome Trust, Medical Research Council (UK) and the University of Cape Town. J.C. Hoving is a Carnegie Corporation postdoctoral researcher at the University of Cape Town. We apologize of all our colleagues whose important contributions we could not cite due to space constraints.

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Signalling C-Type lectin receptors, microbial recognition and immunity
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Signalling C-Type lectin receptors, microbial recognition and immunity

Abstract

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