Signalling C-Type lectin receptors, microbial recognition and immunity

J. Claire Hoving, Gillian J. Watson, Gordon D Brown

Research output: Contribution to journalArticle

131 Citations (Scopus)
4 Downloads (Pure)

Abstract

Signalling C-type lectin receptors (CLRs) are crucial in shaping the immune response to fungal pathogens, but comparably little is known about the role of these receptors in bacterial, viral and parasitic infections. CLRs have many diverse functions depending on the signalling motifs in their cytoplasmic domains, and can induce endocytic, phagocytic, antimicrobial, pro-inflammatory or anti-inflammatory responses which are either protective or not during an infection. Understanding the role of CLRs in shaping anti-microbial immunity offers great potential for the future development of therapeutics for disease intervention. In this review we will focus on the recognition of bacterial, viral and parasitic pathogens by CLRs, and how these receptors influence the outcome of infection. We will also provide a brief update on the role of CLRs in antifungal immunity.
Original languageEnglish
Pages (from-to)185-194
Number of pages10
JournalCellular Microbiology
Volume16
Issue number2
Early online date10 Jan 2014
DOIs
Publication statusPublished - Feb 2014

Fingerprint Dive into the research topics of 'Signalling C-Type lectin receptors, microbial recognition and immunity'. Together they form a unique fingerprint.

  • Cite this