Signalling Pathways Implicated in Obesity Associated Cancers

Janice E. Drew (Corresponding Author)

Research output: Contribution to journalLiterature review

1 Citation (Scopus)
5 Downloads (Pure)

Abstract

Intensive research over recent years has provided irrefutable evidence of links between obesity and the risk of an increasing number of human cancers. The predicted economic burden is causing significant concern. This has prompted investigation of the underlying mechanisms with a focus on deregulated metabolic pathways. A number of metabolic processes and associated signalling pathways are associated with development of obesity. These include a number of interlinking pathways regulating endocrine, redox, inflammation, immunity and lipogenic processes. The identification of deregulated metabolic pathways in obesity with promotion of carcinogenesis has targeted research on the signalling molecules involved. Consequently this mini review is focused on aberrant signalling of deregulated pathways provoked by diets that lead to obesity and their role in carcinogenesis. Knowledge of the signalling molecules involved will assist in directing and establishing dietary manipulation strategies to restore metabolic health in obese individuals. Importantly the identified diversity of signalling pathways linked to obesity related cancers will permit design of more effective combinatorial and multi-targeted cancer therapies in the future.
Original languageEnglish
Pages (from-to)44-49
Number of pages6
JournalThe Open Obesity Journal
Volume6
Issue number1
Publication statusPublished - 2014

Fingerprint

Obesity
Neoplasms
Metabolic Networks and Pathways
Carcinogenesis
Research
Oxidation-Reduction
Immunity
Economics
Diet
Inflammation
Health
Therapeutics

Keywords

  • obesity related cancer
  • metabolic signalling
  • signalling pathways

Cite this

Signalling Pathways Implicated in Obesity Associated Cancers. / Drew, Janice E. (Corresponding Author).

In: The Open Obesity Journal, Vol. 6, No. 1, 2014, p. 44-49.

Research output: Contribution to journalLiterature review

@article{b4346ee3e74647668d442bb53cbe08ed,
title = "Signalling Pathways Implicated in Obesity Associated Cancers",
abstract = "Intensive research over recent years has provided irrefutable evidence of links between obesity and the risk of an increasing number of human cancers. The predicted economic burden is causing significant concern. This has prompted investigation of the underlying mechanisms with a focus on deregulated metabolic pathways. A number of metabolic processes and associated signalling pathways are associated with development of obesity. These include a number of interlinking pathways regulating endocrine, redox, inflammation, immunity and lipogenic processes. The identification of deregulated metabolic pathways in obesity with promotion of carcinogenesis has targeted research on the signalling molecules involved. Consequently this mini review is focused on aberrant signalling of deregulated pathways provoked by diets that lead to obesity and their role in carcinogenesis. Knowledge of the signalling molecules involved will assist in directing and establishing dietary manipulation strategies to restore metabolic health in obese individuals. Importantly the identified diversity of signalling pathways linked to obesity related cancers will permit design of more effective combinatorial and multi-targeted cancer therapies in the future.",
keywords = "obesity related cancer, metabolic signalling, signalling pathways",
author = "Drew, {Janice E.}",
note = "Grant support: The Scottish Government's Rural and Environment Science and Analytical Services Division. Declaration of interest: The author declares that there is no conflict of interest.",
year = "2014",
language = "English",
volume = "6",
pages = "44--49",
journal = "The Open Obesity Journal",
issn = "1876-8237",
publisher = "Bentham Science Publishers B.V.",
number = "1",

}

TY - JOUR

T1 - Signalling Pathways Implicated in Obesity Associated Cancers

AU - Drew, Janice E.

N1 - Grant support: The Scottish Government's Rural and Environment Science and Analytical Services Division. Declaration of interest: The author declares that there is no conflict of interest.

PY - 2014

Y1 - 2014

N2 - Intensive research over recent years has provided irrefutable evidence of links between obesity and the risk of an increasing number of human cancers. The predicted economic burden is causing significant concern. This has prompted investigation of the underlying mechanisms with a focus on deregulated metabolic pathways. A number of metabolic processes and associated signalling pathways are associated with development of obesity. These include a number of interlinking pathways regulating endocrine, redox, inflammation, immunity and lipogenic processes. The identification of deregulated metabolic pathways in obesity with promotion of carcinogenesis has targeted research on the signalling molecules involved. Consequently this mini review is focused on aberrant signalling of deregulated pathways provoked by diets that lead to obesity and their role in carcinogenesis. Knowledge of the signalling molecules involved will assist in directing and establishing dietary manipulation strategies to restore metabolic health in obese individuals. Importantly the identified diversity of signalling pathways linked to obesity related cancers will permit design of more effective combinatorial and multi-targeted cancer therapies in the future.

AB - Intensive research over recent years has provided irrefutable evidence of links between obesity and the risk of an increasing number of human cancers. The predicted economic burden is causing significant concern. This has prompted investigation of the underlying mechanisms with a focus on deregulated metabolic pathways. A number of metabolic processes and associated signalling pathways are associated with development of obesity. These include a number of interlinking pathways regulating endocrine, redox, inflammation, immunity and lipogenic processes. The identification of deregulated metabolic pathways in obesity with promotion of carcinogenesis has targeted research on the signalling molecules involved. Consequently this mini review is focused on aberrant signalling of deregulated pathways provoked by diets that lead to obesity and their role in carcinogenesis. Knowledge of the signalling molecules involved will assist in directing and establishing dietary manipulation strategies to restore metabolic health in obese individuals. Importantly the identified diversity of signalling pathways linked to obesity related cancers will permit design of more effective combinatorial and multi-targeted cancer therapies in the future.

KW - obesity related cancer

KW - metabolic signalling

KW - signalling pathways

M3 - Literature review

VL - 6

SP - 44

EP - 49

JO - The Open Obesity Journal

JF - The Open Obesity Journal

SN - 1876-8237

IS - 1

ER -