Simulating the embolization of blood vessels using magnetic microparticles and acupuncture needle in a magnetic field

Ovidiu Rotariu, G. Iacob, Norval James Colin Strachan, H. Chiriac

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Computer models were developed to simulate the capture and subsequent deposition of magnetic microparticles (MMPs) in a blood vessel adjacent to a ferromagnetic wire (e.g., acupuncture needle) magnetized by a uniform external magnetic field. Process parameter conditions were obtained to enable optimal capture of MMPs into the deposit. It was found that the maximum capture distance of the MMPs was within 0.5-2.0 mm when the particles were superparamagnetic and had large size (>1.0 mum) and relative large flow rates (2.5-5.0 cm/s) as in a healthy artery. It was also found that the deposits were asymmetrical and that their size was between 1.0 and 2.0 mm. For the case of lower flow rates as can be found in a tumor (< 1.0 mm/s) and using small magnetite particles (0.25-2.0 mum) the maximum capture distance was larger, ranging between approximately 0.5 and 6.4 mm, depending on the blood flow rate, the radius of wire, and particle clustering. The range of embolization (deposition) in this later case was between 0.5 and 5.9 mm. The potential of this technique to generate MMPs deposits to embolize blood vessels inhibiting the blood supply and thus facilitating necrosis of tumors located deep within the patient (3-7 cm) is discussed.

Original languageEnglish
Pages (from-to)299-305
Number of pages6
JournalBiotechnology Progress
Volume20
Issue number1
DOIs
Publication statusPublished - Jan 2004

Keywords

  • MAGNETORHEOLOGICAL FLUIDS
  • CANCER-TREATMENT
  • PARTICLES
  • CAPTURE
  • CELL
  • MAGNETOLIPOSOMES
  • FLOW
  • CHEMOTHERAPY
  • FERROFLUIDS
  • SEPARATION

Cite this

Simulating the embolization of blood vessels using magnetic microparticles and acupuncture needle in a magnetic field. / Rotariu, Ovidiu; Iacob, G.; Strachan, Norval James Colin; Chiriac, H.

In: Biotechnology Progress, Vol. 20, No. 1, 01.2004, p. 299-305.

Research output: Contribution to journalArticle

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