Skeletal muscle ATP turnover and muscle fiber conduction velocity are elevated at higher muscle temperatures during maximal power output development in humans

Stuart Robert Gray, Giuseppe De Vito, Myra A Nimmo, Dario Farina, Richard A Ferguson

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

The effect of temperature on skeletal muscle ATP turnover and muscle fiber conduction velocity (MFCV) was studied during maximal power output development in humans. Eight male subjects performed a 6-s maximal sprint on a mechanically braked cycle ergometer under conditions of normal (N) and elevated muscle temperature (ET). Muscle temperature was passively elevated through the combination of hot water immersion and electric blankets. Anaerobic ATP turnover was calculated from analysis of muscle biopsies obtained before and immediately after exercise. MFCV was measured during exercise using surface electromyography. Preexercise muscle temperature was 34.2 degrees C (SD 0.6) in N and 37.5 degrees C (SD 0.6) in ET. During ET, the rate of ATP turnover for phosphocreatine utilization [temperature coefficient (Q10) = 3.8], glycolysis (Q10 = 1.7), and total anaerobic ATP turnover [Q10 = 2.7; 10.8 (SD 1.9) vs. 14.6 mmol x kg(-1) (dry mass) x s(-1) (SD 2.3)] were greater than during N (P <0.05). MFCV was also greater in ET than in N [3.79 (SD 0.47) to 5.55 m/s (SD 0.72)]. Maximal power output (Q10 = 2.2) and pedal rate (Q10 = 1.6) were greater in ET compared with N (P <0.05). The Q10 of maximal and mean power were correlated (P <0.05; R = 0.82 and 0.85, respectively) with the percentage of myosin heavy chain type IIA. The greater power output obtained with passive heating was achieved through an elevated rate of anaerobic ATP turnover and MFCV, possibly due to a greater effect of temperature on power production of fibers, with a predominance of myosin heavy chain IIA at the contraction frequencies reached.
Original languageEnglish
Pages (from-to)R376-382
Number of pages7
JournalAmerican Journal of Physiology-Regulatory Integrative and Comparative Physiology
Volume290
Issue number2
DOIs
Publication statusPublished - 2005

Fingerprint

Human Development
Skeletal Muscle
Adenosine Triphosphate
Muscles
Temperature
Myosin Heavy Chains
Phosphocreatine
Electromyography
Immersion
Glycolysis
Heating
Foot
Biopsy

Keywords

  • Adenosine Triphosphate
  • Adult
  • Biomechanics
  • Body Temperature
  • Electric Conductivity
  • Hot Temperature
  • Humans
  • Male
  • Muscle Fibers, Skeletal
  • Muscle, Skeletal
  • Myosin Heavy Chains
  • Time Factors
  • cycling exercise
  • temperature coefficient
  • myosin heavy chain
  • surface electromyography
  • energy production

Cite this

Skeletal muscle ATP turnover and muscle fiber conduction velocity are elevated at higher muscle temperatures during maximal power output development in humans. / Gray, Stuart Robert; De Vito, Giuseppe; Nimmo, Myra A; Farina, Dario; Ferguson, Richard A.

In: American Journal of Physiology-Regulatory Integrative and Comparative Physiology, Vol. 290, No. 2, 2005, p. R376-382.

Research output: Contribution to journalArticle

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abstract = "The effect of temperature on skeletal muscle ATP turnover and muscle fiber conduction velocity (MFCV) was studied during maximal power output development in humans. Eight male subjects performed a 6-s maximal sprint on a mechanically braked cycle ergometer under conditions of normal (N) and elevated muscle temperature (ET). Muscle temperature was passively elevated through the combination of hot water immersion and electric blankets. Anaerobic ATP turnover was calculated from analysis of muscle biopsies obtained before and immediately after exercise. MFCV was measured during exercise using surface electromyography. Preexercise muscle temperature was 34.2 degrees C (SD 0.6) in N and 37.5 degrees C (SD 0.6) in ET. During ET, the rate of ATP turnover for phosphocreatine utilization [temperature coefficient (Q10) = 3.8], glycolysis (Q10 = 1.7), and total anaerobic ATP turnover [Q10 = 2.7; 10.8 (SD 1.9) vs. 14.6 mmol x kg(-1) (dry mass) x s(-1) (SD 2.3)] were greater than during N (P <0.05). MFCV was also greater in ET than in N [3.79 (SD 0.47) to 5.55 m/s (SD 0.72)]. Maximal power output (Q10 = 2.2) and pedal rate (Q10 = 1.6) were greater in ET compared with N (P <0.05). The Q10 of maximal and mean power were correlated (P <0.05; R = 0.82 and 0.85, respectively) with the percentage of myosin heavy chain type IIA. The greater power output obtained with passive heating was achieved through an elevated rate of anaerobic ATP turnover and MFCV, possibly due to a greater effect of temperature on power production of fibers, with a predominance of myosin heavy chain IIA at the contraction frequencies reached.",
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T1 - Skeletal muscle ATP turnover and muscle fiber conduction velocity are elevated at higher muscle temperatures during maximal power output development in humans

AU - Gray, Stuart Robert

AU - De Vito, Giuseppe

AU - Nimmo, Myra A

AU - Farina, Dario

AU - Ferguson, Richard A

PY - 2005

Y1 - 2005

N2 - The effect of temperature on skeletal muscle ATP turnover and muscle fiber conduction velocity (MFCV) was studied during maximal power output development in humans. Eight male subjects performed a 6-s maximal sprint on a mechanically braked cycle ergometer under conditions of normal (N) and elevated muscle temperature (ET). Muscle temperature was passively elevated through the combination of hot water immersion and electric blankets. Anaerobic ATP turnover was calculated from analysis of muscle biopsies obtained before and immediately after exercise. MFCV was measured during exercise using surface electromyography. Preexercise muscle temperature was 34.2 degrees C (SD 0.6) in N and 37.5 degrees C (SD 0.6) in ET. During ET, the rate of ATP turnover for phosphocreatine utilization [temperature coefficient (Q10) = 3.8], glycolysis (Q10 = 1.7), and total anaerobic ATP turnover [Q10 = 2.7; 10.8 (SD 1.9) vs. 14.6 mmol x kg(-1) (dry mass) x s(-1) (SD 2.3)] were greater than during N (P <0.05). MFCV was also greater in ET than in N [3.79 (SD 0.47) to 5.55 m/s (SD 0.72)]. Maximal power output (Q10 = 2.2) and pedal rate (Q10 = 1.6) were greater in ET compared with N (P <0.05). The Q10 of maximal and mean power were correlated (P <0.05; R = 0.82 and 0.85, respectively) with the percentage of myosin heavy chain type IIA. The greater power output obtained with passive heating was achieved through an elevated rate of anaerobic ATP turnover and MFCV, possibly due to a greater effect of temperature on power production of fibers, with a predominance of myosin heavy chain IIA at the contraction frequencies reached.

AB - The effect of temperature on skeletal muscle ATP turnover and muscle fiber conduction velocity (MFCV) was studied during maximal power output development in humans. Eight male subjects performed a 6-s maximal sprint on a mechanically braked cycle ergometer under conditions of normal (N) and elevated muscle temperature (ET). Muscle temperature was passively elevated through the combination of hot water immersion and electric blankets. Anaerobic ATP turnover was calculated from analysis of muscle biopsies obtained before and immediately after exercise. MFCV was measured during exercise using surface electromyography. Preexercise muscle temperature was 34.2 degrees C (SD 0.6) in N and 37.5 degrees C (SD 0.6) in ET. During ET, the rate of ATP turnover for phosphocreatine utilization [temperature coefficient (Q10) = 3.8], glycolysis (Q10 = 1.7), and total anaerobic ATP turnover [Q10 = 2.7; 10.8 (SD 1.9) vs. 14.6 mmol x kg(-1) (dry mass) x s(-1) (SD 2.3)] were greater than during N (P <0.05). MFCV was also greater in ET than in N [3.79 (SD 0.47) to 5.55 m/s (SD 0.72)]. Maximal power output (Q10 = 2.2) and pedal rate (Q10 = 1.6) were greater in ET compared with N (P <0.05). The Q10 of maximal and mean power were correlated (P <0.05; R = 0.82 and 0.85, respectively) with the percentage of myosin heavy chain type IIA. The greater power output obtained with passive heating was achieved through an elevated rate of anaerobic ATP turnover and MFCV, possibly due to a greater effect of temperature on power production of fibers, with a predominance of myosin heavy chain IIA at the contraction frequencies reached.

KW - Adenosine Triphosphate

KW - Adult

KW - Biomechanics

KW - Body Temperature

KW - Electric Conductivity

KW - Hot Temperature

KW - Humans

KW - Male

KW - Muscle Fibers, Skeletal

KW - Muscle, Skeletal

KW - Myosin Heavy Chains

KW - Time Factors

KW - cycling exercise

KW - temperature coefficient

KW - myosin heavy chain

KW - surface electromyography

KW - energy production

U2 - 10.1152/ajpregu.00291.2005

DO - 10.1152/ajpregu.00291.2005

M3 - Article

C2 - 16166210

VL - 290

SP - R376-382

JO - American Journal of Physiology-Regulatory Integrative and Comparative Physiology

JF - American Journal of Physiology-Regulatory Integrative and Comparative Physiology

SN - 0363-6119

IS - 2

ER -