Skeletal tissue engineering: opportunities and challenges

F P Luyten, F Dell'Accio, Cosimo De Bari

Research output: Contribution to journalArticlepeer-review

45 Citations (Scopus)


Tissue engineering is a field of biomedicine that is growing rapidly and is critically driven by scientific advances in the areas of developmental and cell biology and biomaterial sciences. Regeneration of skeletal tissues is among the most promising areas of biological tissue repair and is providing a broad spectrum of potential clinical applications, including joint resurfacing. The availability of novel tools such as pluripotent stem cells, morphogens, smart biomaterials and gene transfer technologies, makes us dream of many exciting novel therapeutic approaches. Despite these opportunities in regenerative medicine, good clinical practice requires the clinician to question the consistency, reproducibility, validation and appropriate regulation of these new biological treatments.
Original languageEnglish
Pages (from-to)759-769
Number of pages11
JournalBest Practice & Research Clinical Rheumatology
Issue number5
Publication statusPublished - 1 Dec 2001


  • Biocompatible Materials
  • Biomedical Engineering
  • Bone Regeneration
  • Bone Transplantation
  • Bone and Bones
  • Cartilage, Articular
  • Gene Therapy
  • Hematopoietic Stem Cell Transplantation
  • Humans
  • Orthopedics
  • Osteoarthritis
  • Tissue Engineering


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