TY - JOUR
T1 - Skin blood flow after transdermal S-nitrosothio-acetylglucose.
AU - Khan, Faisal
AU - Greig, Iain Robert
AU - Newton, David J
AU - Butler, Anthony R
AU - Belch, Jill J F
PY - 1997/8/1
Y1 - 1997/8/1
N2 - The role of nitric oxide (NO) in skin microvessels is unclear because of the variable effects of NG-monomethyl-L-arginine (L-NMMA) on skin blood flow.1, 2 Although 80–90% of skin blood flow serves a thermoregulatory function, it is the nutritional component that is clinically important. Nitrovasodilators, such as sodium nitroprusside and glyceryl trinitrate, are difficult to study in cutaneous microvessels because they require extensive metabolism before they release NO. S-nitrosothiols release NO and are vasodilators in animals.3 S-nitrosothio-acetylglucose (SNAG) acts as a vasodilator in the isolated rat tail artery.4 We now examine the effects of transdermal application of SNAG on human skin microvessels. We measured skin perfusion with laser doppler imaging and skin oxygenation by lightguide spectrophotometry.
AB - The role of nitric oxide (NO) in skin microvessels is unclear because of the variable effects of NG-monomethyl-L-arginine (L-NMMA) on skin blood flow.1, 2 Although 80–90% of skin blood flow serves a thermoregulatory function, it is the nutritional component that is clinically important. Nitrovasodilators, such as sodium nitroprusside and glyceryl trinitrate, are difficult to study in cutaneous microvessels because they require extensive metabolism before they release NO. S-nitrosothiols release NO and are vasodilators in animals.3 S-nitrosothio-acetylglucose (SNAG) acts as a vasodilator in the isolated rat tail artery.4 We now examine the effects of transdermal application of SNAG on human skin microvessels. We measured skin perfusion with laser doppler imaging and skin oxygenation by lightguide spectrophotometry.
UR - https://doi.org/10.1016/S0140-6736(05)64133-5
U2 - 10.1016/s0140-6736(05)64133-5
DO - 10.1016/s0140-6736(05)64133-5
M3 - Article
C2 - 9259659
VL - 350
SP - 410
EP - 411
JO - Lancet (London, England)
JF - Lancet (London, England)
IS - 9075
ER -