Slow sites in an exclusion process with limited resources

Christopher A Brackley, M Carmen Romano, Marco Thiel

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

We introduce slow bottleneck sites into a recent extension of the totally asymmetric exclusion process where hopping rates are allowed to vary dynamically with the availability of resources. In the context of messenger RNA (mRNA) translation in biology, this refers to the availability of amino acid-transfer-RNA (aa-tRNA) complexes which act as the source of amino acids for protein production. We study a simple designer mRNA with a single defect codon in the center. As well as the familiar queuing behavior we also observe a regime within the queuing phase where the queue becomes less severe as the aa-tRNAs become depleted.
Original languageEnglish
Article number051920
JournalPhysical Review. E, Statistical, Nonlinear and Soft Matter Physics
Volume82
Issue number5 Pt 1
DOIs
Publication statusPublished - Nov 2010

Fingerprint

ribonucleic acids
Exclusion Process
Queuing
exclusion
Messenger RNA
Amino Acids
resources
Availability
Asymmetric Exclusion Process
Resources
availability
amino acids
Biology
Queue
Defects
Vary
Protein
biology
proteins
defects

Cite this

Slow sites in an exclusion process with limited resources. / Brackley, Christopher A; Romano, M Carmen; Thiel, Marco.

In: Physical Review. E, Statistical, Nonlinear and Soft Matter Physics, Vol. 82, No. 5 Pt 1, 051920, 11.2010.

Research output: Contribution to journalArticle

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