Sol-Gel Synthesis and in-vitro Cell Compatibility Analysis of Silicate-Containing Biodegradable Hybrid Gels

Kanji Tsuru, Zoe Robertson, Basil Annaz, Iain Ronald Gibson

Research output: Chapter in Book/Report/Conference proceedingChapter

7 Citations (Scopus)

Abstract

Novel hybrid gels in the system gelatin-GPTMS-TEOS were prepared via a sol-gel route, and their ability to release Si(IV) was examined using MG63 osteoblast-like cell culture. The amount of Si released and the release rate were controllable by changing the mixing ratio of GPTMS and TEOS. In addition, the hybrids had biocompatible surfaces. It is expected that the hybrids will be utilized for the investigation of the effect of Si on cell differentiation and tissue regeneration.
Original languageEnglish
Title of host publicationBioceramics
EditorsGuy Daculsi, Pierre Layrolle
Place of PublicationZurich, Switzerland
PublisherTrans Tech Publications Ltd
Pages447-450
Number of pages4
Volume20
ISBN (Print)9780878494576, 978-0878494576
Publication statusPublished - 30 Mar 2008
Event20th International Symposium on Ceramics in Medicine - Nantes, France
Duration: 24 Oct 200726 Oct 2007

Publication series

NameKey Engineering Materials
PublisherTrans Tech Publications Ltd
Volume361-363
ISSN (Print)1013-9826

Conference

Conference20th International Symposium on Ceramics in Medicine
CountryFrance
CityNantes
Period24/10/0726/10/07

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Keywords

  • cell-material interactions
  • tissue engineering
  • scaffolds
  • organic-inorganic hybrids
  • biodegradability

Cite this

Tsuru, K., Robertson, Z., Annaz, B., & Gibson, I. R. (2008). Sol-Gel Synthesis and in-vitro Cell Compatibility Analysis of Silicate-Containing Biodegradable Hybrid Gels. In G. Daculsi, & P. Layrolle (Eds.), Bioceramics (Vol. 20, pp. 447-450). (Key Engineering Materials; Vol. 361-363). Trans Tech Publications Ltd.