Solid phase synthesis of tertiary amines on amide REM resins: Grignard and metal hydride compatible resins

M J  Plater; A M  Murdoch; J R  Morphy; Z  Rankovic; D C  Rees

doi:10.1021/cc000023+

Solid phase synthesis of tertiary amines on amide REM resins: Grignard and metal hydride compatible resins

M J Plater, A M Murdoch, J R Morphy, Z Rankovic, D C Rees

Chemistry

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16 Citations (Scopus)

Abstract

Four new amide REM resins (AM REM 2-5) are described, and their use is illustrated for the synthesis of tertiary amines 6-9 and 13-16. Amide REM resins 4 and 5, which have a phenyl ring attached to the amide nitrogen, are found to give superior product yields and purities, and the resins are stable to a wider range of reagents and conditions compared to REM resin 1.

Original language	English
Pages (from-to)	508-512
Number of pages	5
Journal	Journal of Combinatorial Chemistry
Volume	2
DOIs	https://doi.org/10.1021/cc000023+
Publication status	Published - 2000

Keywords

ORGANIC-SYNTHESIS
SUPPORT
LINKER
TERFENADINE

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10.1021/cc000023+

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title = "Solid phase synthesis of tertiary amines on amide REM resins: Grignard and metal hydride compatible resins",

abstract = "Four new amide REM resins (AM REM 2-5) are described, and their use is illustrated for the synthesis of tertiary amines 6-9 and 13-16. Amide REM resins 4 and 5, which have a phenyl ring attached to the amide nitrogen, are found to give superior product yields and purities, and the resins are stable to a wider range of reagents and conditions compared to REM resin 1.",

keywords = "ORGANIC-SYNTHESIS, SUPPORT, LINKER, TERFENADINE",

author = "Plater, {M J} and Murdoch, {A M} and Morphy, {J R} and Z Rankovic and Rees, {D C}",

year = "2000",

doi = "10.1021/cc000023+",

language = "English",

volume = "2",

pages = "508--512",

journal = "Journal of Combinatorial Chemistry",

issn = "1520-4766",

publisher = "American Chemical Society",

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TY - JOUR

T1 - Solid phase synthesis of tertiary amines on amide REM resins: Grignard and metal hydride compatible resins

AU - Plater, M J

AU - Murdoch, A M

AU - Morphy, J R

AU - Rankovic, Z

AU - Rees, D C

PY - 2000

Y1 - 2000

N2 - Four new amide REM resins (AM REM 2-5) are described, and their use is illustrated for the synthesis of tertiary amines 6-9 and 13-16. Amide REM resins 4 and 5, which have a phenyl ring attached to the amide nitrogen, are found to give superior product yields and purities, and the resins are stable to a wider range of reagents and conditions compared to REM resin 1.

AB - Four new amide REM resins (AM REM 2-5) are described, and their use is illustrated for the synthesis of tertiary amines 6-9 and 13-16. Amide REM resins 4 and 5, which have a phenyl ring attached to the amide nitrogen, are found to give superior product yields and purities, and the resins are stable to a wider range of reagents and conditions compared to REM resin 1.

KW - ORGANIC-SYNTHESIS

KW - SUPPORT

KW - LINKER

KW - TERFENADINE

U2 - 10.1021/cc000023+

DO - 10.1021/cc000023+

M3 - Article

VL - 2

SP - 508

EP - 512

JO - Journal of Combinatorial Chemistry

JF - Journal of Combinatorial Chemistry

SN - 1520-4766

ER -

Solid phase synthesis of tertiary amines on amide REM resins: Grignard and metal hydride compatible resins

Abstract

Keywords

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