Solid phase synthesis of tertiary amines on amide REM resins: Grignard and metal hydride compatible resins

M J Plater, A M Murdoch, J R Morphy, Z Rankovic, D C Rees

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Abstract

Four new amide REM resins (AM REM 2-5) are described, and their use is illustrated for the synthesis of tertiary amines 6-9 and 13-16. Amide REM resins 4 and 5, which have a phenyl ring attached to the amide nitrogen, are found to give superior product yields and purities, and the resins are stable to a wider range of reagents and conditions compared to REM resin 1.

Original languageEnglish
Pages (from-to)508-512
Number of pages5
JournalJournal of Combinatorial Chemistry
Volume2
DOIs
Publication statusPublished - 2000

Keywords

  • ORGANIC-SYNTHESIS
  • SUPPORT
  • LINKER
  • TERFENADINE

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