Soluble IL-2 receptor and CD25 cells in psoriasis: effects of cyclosporin A and PUVA therapy

Jonathan Duncan, C Horrocks, Anthony Ormerod, A V Powles, P H Whiting, L Fry, A W Thomson

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Abstract

A study was conducted to quantify soluble IL-2 receptor (sIL-2R) levels in sera of 57 chronic plaque psoriasis patients and correlate these measurements with disease activity and the number of IL-2R-positive (CD25+) lymphocytes in lesional biopsies of 11 cyclosporin A (CsA) and 13 psoralen plus ultraviolet radiation (PUVA) treated patients. Levels of sIL-2R showed a strong correlation with the psoriasis area and severity index (PASI). CsA and PUVA significantly reduced the PASI and sIL-2R levels to a similar degree after 4 weeks of treatment. Although the majority of CsA-treated patients who were biopsied showed reductions in lesional CD25+ cells, these did not reach statistical significance; in five patients biopsied who had PUVA treatment, no consistent effect on the numbers of CD25+ cells was observed. A significant correlation was found between CD25+ cells in lesional biopsies and the PASI score.
Original languageEnglish
Pages (from-to)293-296
Number of pages4
JournalClinical and Experimental Immunology
Volume85
Issue number2
DOIs
Publication statusPublished - 1 Aug 1991

Keywords

  • Adult
  • Cyclosporins
  • Humans
  • PUVA Therapy
  • Psoriasis
  • Receptors, Interleukin-2
  • T-Lymphocytes

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    Duncan, J., Horrocks, C., Ormerod, A., Powles, A. V., Whiting, P. H., Fry, L., & Thomson, A. W. (1991). Soluble IL-2 receptor and CD25 cells in psoriasis: effects of cyclosporin A and PUVA therapy. Clinical and Experimental Immunology, 85(2), 293-296. https://doi.org/10.1111/j.1365-2249.1991.tb05721.x