Soluble IL-2 receptor and CD25 cells in psoriasis

effects of cyclosporin A and PUVA therapy

Jonathan Duncan, C Horrocks, Anthony Ormerod, A V Powles, P H Whiting, L Fry, A W Thomson

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

A study was conducted to quantify soluble IL-2 receptor (sIL-2R) levels in sera of 57 chronic plaque psoriasis patients and correlate these measurements with disease activity and the number of IL-2R-positive (CD25+) lymphocytes in lesional biopsies of 11 cyclosporin A (CsA) and 13 psoralen plus ultraviolet radiation (PUVA) treated patients. Levels of sIL-2R showed a strong correlation with the psoriasis area and severity index (PASI). CsA and PUVA significantly reduced the PASI and sIL-2R levels to a similar degree after 4 weeks of treatment. Although the majority of CsA-treated patients who were biopsied showed reductions in lesional CD25+ cells, these did not reach statistical significance; in five patients biopsied who had PUVA treatment, no consistent effect on the numbers of CD25+ cells was observed. A significant correlation was found between CD25+ cells in lesional biopsies and the PASI score.
Original languageEnglish
Pages (from-to)293-296
Number of pages4
JournalClinical and Experimental Immunology
Volume85
Issue number2
DOIs
Publication statusPublished - 1 Aug 1991

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Ultraviolet Therapy
Interleukin-2 Receptors
Psoriasis
Cyclosporine
Radiotherapy
Radiation
Ficusin
Biopsy
Cell Count
Lymphocytes
Therapeutics
Serum

Keywords

  • Adult
  • Cyclosporins
  • Humans
  • PUVA Therapy
  • Psoriasis
  • Receptors, Interleukin-2
  • T-Lymphocytes

Cite this

Duncan, J., Horrocks, C., Ormerod, A., Powles, A. V., Whiting, P. H., Fry, L., & Thomson, A. W. (1991). Soluble IL-2 receptor and CD25 cells in psoriasis: effects of cyclosporin A and PUVA therapy. Clinical and Experimental Immunology, 85(2), 293-296. https://doi.org/10.1111/j.1365-2249.1991.tb05721.x

Soluble IL-2 receptor and CD25 cells in psoriasis : effects of cyclosporin A and PUVA therapy. / Duncan, Jonathan; Horrocks, C; Ormerod, Anthony; Powles, A V; Whiting, P H; Fry, L; Thomson, A W.

In: Clinical and Experimental Immunology, Vol. 85, No. 2, 01.08.1991, p. 293-296.

Research output: Contribution to journalArticle

Duncan, J, Horrocks, C, Ormerod, A, Powles, AV, Whiting, PH, Fry, L & Thomson, AW 1991, 'Soluble IL-2 receptor and CD25 cells in psoriasis: effects of cyclosporin A and PUVA therapy', Clinical and Experimental Immunology, vol. 85, no. 2, pp. 293-296. https://doi.org/10.1111/j.1365-2249.1991.tb05721.x
Duncan, Jonathan ; Horrocks, C ; Ormerod, Anthony ; Powles, A V ; Whiting, P H ; Fry, L ; Thomson, A W. / Soluble IL-2 receptor and CD25 cells in psoriasis : effects of cyclosporin A and PUVA therapy. In: Clinical and Experimental Immunology. 1991 ; Vol. 85, No. 2. pp. 293-296.
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