Spatial and temporal patterns of cell division during early Xenopus embryogenesis

Yasushi Saka, J C Smith

Research output: Contribution to journalArticle

133 Citations (Scopus)

Abstract

We describe the spatial and temporal patterns of cell division in the early Xenopus embryo, concentrating on the period between the midblastula transition and the early tailbud stage. Mitotic cells were identified using an antibody recognising phosphorylated histone H3. At least four observations are of interest. First, axial mesodermal cells, including prospective notochord, stop dividing after involution and may not divide thereafter. Second, cell division is more pronounced in the neural plate than in nonneural ectoderm, and the pattern of cell division becomes further refined as neurogenesis proceeds. Third, cells in the cement gland cease proliferation completely as they begin to accumulate pigment. Finally, the precursors of peripheral sensory organs such as the ear and olfactory placode undergo active cell proliferation when they arise from the sensorial layer of the ectoderm. These observations and others should provide a platform to study the relationship between the regulation of developmental processes and the cell cycle during Xenopus embryogenesis.
Original languageEnglish
Pages (from-to)307-318
Number of pages12
JournalDevelopmental Biology
Volume229
Issue number2
DOIs
Publication statusPublished - 15 Jan 2001

Fingerprint

Xenopus
Cell Division
Embryonic Development
Ectoderm
Neural Plate
Notochord
Neurogenesis
Histones
Ear
Cell Cycle
Embryonic Structures
Cell Proliferation
Antibodies

Keywords

  • Animals
  • Cell Cycle
  • Cell Differentiation
  • Cell Division
  • Embryo, Nonmammalian
  • Embryonic Induction
  • Gastrula
  • Histones
  • Mesoderm
  • Morphogenesis
  • Nervous System
  • Notochord
  • Phosphorylation
  • Sense Organs
  • Xenopus

Cite this

Spatial and temporal patterns of cell division during early Xenopus embryogenesis. / Saka, Yasushi; Smith, J C.

In: Developmental Biology, Vol. 229, No. 2, 15.01.2001, p. 307-318.

Research output: Contribution to journalArticle

Saka, Yasushi ; Smith, J C. / Spatial and temporal patterns of cell division during early Xenopus embryogenesis. In: Developmental Biology. 2001 ; Vol. 229, No. 2. pp. 307-318.
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