Spatial distribution of intraventricular dyssynchrony in relation to infarct location:  a cardiovascular magnetic resonance tissue synchronization mapping study

Paul William Foley; Kayvan Khadjooi; Shajil Chall; Berthed Stegemann; Simona P. Ungureanu; Russell Ea Smith; Michael Frenneaux; Francisco Leyva

doi:10.1016/j.jacc.2008.02.006

Abstract

Background: In echocardiographic studies, dyssynchrony is often equated with nonviability and it is thought that dyssynchrony is greatest over the infarct site. We have used magnetic resonance tissue synchronization mapping (CMR-TSM) to explore the spatial distribution of dyssynchrony in patients with myocardial infarctions affecting the anteroseptal and posterolateral left ventricular (LV) territories.

Methods: 56 patients (age 66.9 ± 10.1 yrs, LVEF 25.5 ± 12.3%) and 23 age-matched healthy controls underwent CMR-TSM, which provided the global tissue synchronization index (CMR-TSIglobal), the standard deviation of the time-to-peak inward wall motion for each of 6 segments per LV short-axis slice, in up to 10 slices from LV base to apex (up to 60 segments); a regional measure, expressed as the CMR-TSI for segments in either the infarct zone (CMR-TSI scar) or remote from the infarct zone (CMR-TSI remote).

Results: CMR-TSIglobal was higher in patients with anteroseptal (104 ± 39 ms, p<0.0001) and posterolateral infarcts (126 ± 70, p<0.0001) than in controls (42 ± 12 ms). There was no differences in CMR-TSI scar and CMR-TSI remote between the anteroseptal or posterolateral territories (see Table).

Conclusions: In patients with ischemic cardiomyopathy, radial dyssynchrony is as
marked in the infarct zone as in remote myocardium. These findings imply that localised mechanical dyssynchrony does not equate with non-viability.

Original language	English
Pages (from-to)	A158
Number of pages	1
Journal	Journal of the American College of Cardiology
Volume	51
Issue number	10, Supplement 1
DOIs	https://doi.org/10.1016/j.jacc.2008.02.006
Publication status	Published - 11 Mar 2008

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Foley, P. W., Khadjooi, K., Chall, S., Stegemann, B., Ungureanu, S. P., Smith, R. E., Frenneaux, M., & Leyva, F. (2008). Spatial distribution of intraventricular dyssynchrony in relation to infarct location: a cardiovascular magnetic resonance tissue synchronization mapping study. Journal of the American College of Cardiology, 51(10, Supplement 1), A158. https://doi.org/10.1016/j.jacc.2008.02.006

Spatial distribution of intraventricular dyssynchrony in relation to infarct location : a cardiovascular magnetic resonance tissue synchronization mapping study. / Foley, Paul William; Khadjooi, Kayvan; Chall, Shajil et al.

In: Journal of the American College of Cardiology, Vol. 51, No. 10, Supplement 1, 11.03.2008, p. A158.

Research output: Contribution to journal › Abstract › peer-review

Foley, PW, Khadjooi, K, Chall, S, Stegemann, B, Ungureanu, SP, Smith, RE, Frenneaux, M & Leyva, F 2008, 'Spatial distribution of intraventricular dyssynchrony in relation to infarct location: a cardiovascular magnetic resonance tissue synchronization mapping study', Journal of the American College of Cardiology, vol. 51, no. 10, Supplement 1, pp. A158. https://doi.org/10.1016/j.jacc.2008.02.006

@article{50f21a3a9d564bdaba93962c4586b411,

title = "Spatial distribution of intraventricular dyssynchrony in relation to infarct location: a cardiovascular magnetic resonance tissue synchronization mapping study",

abstract = "Background: In echocardiographic studies, dyssynchrony is often equated with nonviability and it is thought that dyssynchrony is greatest over the infarct site. We have used magnetic resonance tissue synchronization mapping (CMR-TSM) to explore the spatial distribution of dyssynchrony in patients with myocardial infarctions affecting the anteroseptal and posterolateral left ventricular (LV) territories. Methods: 56 patients (age 66.9 ± 10.1 yrs, LVEF 25.5 ± 12.3%) and 23 age-matched healthy controls underwent CMR-TSM, which provided the global tissue synchronization index (CMR-TSIglobal), the standard deviation of the time-to-peak inward wall motion for each of 6 segments per LV short-axis slice, in up to 10 slices from LV base to apex (up to 60 segments); a regional measure, expressed as the CMR-TSI for segments in either the infarct zone (CMR-TSI scar) or remote from the infarct zone (CMR-TSI remote). Results: CMR-TSIglobal was higher in patients with anteroseptal (104 ± 39 ms, p<0.0001) and posterolateral infarcts (126 ± 70, p<0.0001) than in controls (42 ± 12 ms). There was no differences in CMR-TSI scar and CMR-TSI remote between the anteroseptal or posterolateral territories (see Table). Conclusions: In patients with ischemic cardiomyopathy, radial dyssynchrony is as marked in the infarct zone as in remote myocardium. These findings imply that localised mechanical dyssynchrony does not equate with non-viability.",

author = "Foley, {Paul William} and Kayvan Khadjooi and Shajil Chall and Berthed Stegemann and Ungureanu, {Simona P.} and Smith, {Russell Ea} and Michael Frenneaux and Francisco Leyva",

year = "2008",

month = mar,

day = "11",

doi = "10.1016/j.jacc.2008.02.006",

language = "English",

volume = "51",

pages = "A158",

journal = "Journal of the American College of Cardiology",

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TY - JOUR

T1 - Spatial distribution of intraventricular dyssynchrony in relation to infarct location

T2 - a cardiovascular magnetic resonance tissue synchronization mapping study

AU - Foley, Paul William

AU - Khadjooi, Kayvan

AU - Chall, Shajil

AU - Stegemann, Berthed

AU - Ungureanu, Simona P.

AU - Smith, Russell Ea

AU - Frenneaux, Michael

AU - Leyva, Francisco

PY - 2008/3/11

Y1 - 2008/3/11

N2 - Background: In echocardiographic studies, dyssynchrony is often equated with nonviability and it is thought that dyssynchrony is greatest over the infarct site. We have used magnetic resonance tissue synchronization mapping (CMR-TSM) to explore the spatial distribution of dyssynchrony in patients with myocardial infarctions affecting the anteroseptal and posterolateral left ventricular (LV) territories. Methods: 56 patients (age 66.9 ± 10.1 yrs, LVEF 25.5 ± 12.3%) and 23 age-matched healthy controls underwent CMR-TSM, which provided the global tissue synchronization index (CMR-TSIglobal), the standard deviation of the time-to-peak inward wall motion for each of 6 segments per LV short-axis slice, in up to 10 slices from LV base to apex (up to 60 segments); a regional measure, expressed as the CMR-TSI for segments in either the infarct zone (CMR-TSI scar) or remote from the infarct zone (CMR-TSI remote). Results: CMR-TSIglobal was higher in patients with anteroseptal (104 ± 39 ms, p<0.0001) and posterolateral infarcts (126 ± 70, p<0.0001) than in controls (42 ± 12 ms). There was no differences in CMR-TSI scar and CMR-TSI remote between the anteroseptal or posterolateral territories (see Table). Conclusions: In patients with ischemic cardiomyopathy, radial dyssynchrony is as marked in the infarct zone as in remote myocardium. These findings imply that localised mechanical dyssynchrony does not equate with non-viability.

AB - Background: In echocardiographic studies, dyssynchrony is often equated with nonviability and it is thought that dyssynchrony is greatest over the infarct site. We have used magnetic resonance tissue synchronization mapping (CMR-TSM) to explore the spatial distribution of dyssynchrony in patients with myocardial infarctions affecting the anteroseptal and posterolateral left ventricular (LV) territories. Methods: 56 patients (age 66.9 ± 10.1 yrs, LVEF 25.5 ± 12.3%) and 23 age-matched healthy controls underwent CMR-TSM, which provided the global tissue synchronization index (CMR-TSIglobal), the standard deviation of the time-to-peak inward wall motion for each of 6 segments per LV short-axis slice, in up to 10 slices from LV base to apex (up to 60 segments); a regional measure, expressed as the CMR-TSI for segments in either the infarct zone (CMR-TSI scar) or remote from the infarct zone (CMR-TSI remote). Results: CMR-TSIglobal was higher in patients with anteroseptal (104 ± 39 ms, p<0.0001) and posterolateral infarcts (126 ± 70, p<0.0001) than in controls (42 ± 12 ms). There was no differences in CMR-TSI scar and CMR-TSI remote between the anteroseptal or posterolateral territories (see Table). Conclusions: In patients with ischemic cardiomyopathy, radial dyssynchrony is as marked in the infarct zone as in remote myocardium. These findings imply that localised mechanical dyssynchrony does not equate with non-viability.

U2 - 10.1016/j.jacc.2008.02.006

DO - 10.1016/j.jacc.2008.02.006

M3 - Abstract

VL - 51

SP - A158

JO - Journal of the American College of Cardiology

JF - Journal of the American College of Cardiology

SN - 0735-1097

IS - 10, Supplement 1

ER -

Spatial distribution of intraventricular dyssynchrony in relation to infarct location: a cardiovascular magnetic resonance tissue synchronization mapping study

Abstract

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