SRY: a transcriptional activator of mammalian testis determination

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45 Citations (Scopus)

Abstract

Sry (sex-determining region Y) is the sex-determining gene on the mammalian Y chromosome, which encodes a transcription factor containing a DNA-binding domain characteristic of some high mobility group proteins (HMG box). It is the founder member of the Sox (Sry-related HMG box) gene family and is therefore classified in the Sox A group. In mice, the transient expression of Sry between 10.5 and 12.5 dpc triggers the differentiation of Sertoli cells from the supporting cell precursor lineage, which would otherwise give rise to granulosa cells in ovaries. However, little was known about the target genes of SRY and molecular mechanisms how SRY leads to testis development. Recent work has provided evidence that SRY binds directly to a testis-specific enhancer of Sox9 (TES) and activates Sox9 expression in co-operation with steroidogenic factor 1 (SF1). Furthermore, this SRY action is limited to a certain time period during embryogenesis.

Original languageEnglish
Pages (from-to)417-420
Number of pages4
JournalInternational Journal of Biochemistry & Cell Biology
Volume42
Issue number3
Early online date18 Dec 2009
DOIs
Publication statusPublished - Mar 2010

Keywords

  • animals
  • male
  • mammals
  • models, genetic
  • sex determination processes
  • sex-determining region Y protein
  • testis
  • trans-activators

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