Stable isotope pilot study of exchangeable copper kinetics in human blood plasma

Tony I. Venelinov, John H. Beattie, Jack R. Dainty, Wendy J. Hollands, Susan J. Fairweather-Tait, Linda J. Harvey

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    6 Citations (Scopus)

    Abstract

    To develop further our understanding of initial dietary copper metabolism, a method has been developed to separate plasma copper that is bound to albumin, from that bound to ceruloplasmin. This method has been tested using plasma samples from a pilot study involving six human volunteers who consumed 3 mg oral doses of the stable isotope Cu-65 and gave blood samples at timed intervals up to 7 days. The results suggest that this method can be used to monitor dynamic fluctuations in newly absorbed copper over a short time frame. (C) 2007 Elsevier GmbH. All rights reserved.

    Original languageEnglish
    Pages (from-to)138-140
    Number of pages3
    JournalJournal of Trace Elements in Medicine and Biology
    Volume21
    Issue number2
    DOIs
    Publication statusPublished - Jun 2007

    Keywords

    • exchangeable copper
    • copper metabolism
    • dialysis-chelex
    • isotope ratio
    • ICP-MS
    • absorption

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