Stable isotope pilot study of exchangeable copper kinetics in human blood plasma

Tony I. Venelinov, John H. Beattie, Jack R. Dainty, Wendy J. Hollands, Susan J. Fairweather-Tait, Linda J. Harvey

    Research output: Contribution to journalArticle

    5 Citations (Scopus)

    Abstract

    To develop further our understanding of initial dietary copper metabolism, a method has been developed to separate plasma copper that is bound to albumin, from that bound to ceruloplasmin. This method has been tested using plasma samples from a pilot study involving six human volunteers who consumed 3 mg oral doses of the stable isotope Cu-65 and gave blood samples at timed intervals up to 7 days. The results suggest that this method can be used to monitor dynamic fluctuations in newly absorbed copper over a short time frame. (C) 2007 Elsevier GmbH. All rights reserved.

    Original languageEnglish
    Pages (from-to)138-140
    Number of pages3
    JournalJournal of Trace Elements in Medicine and Biology
    Volume21
    Issue number2
    DOIs
    Publication statusPublished - Jun 2007

    Keywords

    • exchangeable copper
    • copper metabolism
    • dialysis-chelex
    • isotope ratio
    • ICP-MS
    • absorption

    Cite this

    Venelinov, T. I., Beattie, J. H., Dainty, J. R., Hollands, W. J., Fairweather-Tait, S. J., & Harvey, L. J. (2007). Stable isotope pilot study of exchangeable copper kinetics in human blood plasma. Journal of Trace Elements in Medicine and Biology, 21(2), 138-140. https://doi.org/10.1016/j.jtemb.2007.01.001

    Stable isotope pilot study of exchangeable copper kinetics in human blood plasma. / Venelinov, Tony I.; Beattie, John H.; Dainty, Jack R.; Hollands, Wendy J.; Fairweather-Tait, Susan J.; Harvey, Linda J.

    In: Journal of Trace Elements in Medicine and Biology, Vol. 21, No. 2, 06.2007, p. 138-140.

    Research output: Contribution to journalArticle

    Venelinov, TI, Beattie, JH, Dainty, JR, Hollands, WJ, Fairweather-Tait, SJ & Harvey, LJ 2007, 'Stable isotope pilot study of exchangeable copper kinetics in human blood plasma', Journal of Trace Elements in Medicine and Biology, vol. 21, no. 2, pp. 138-140. https://doi.org/10.1016/j.jtemb.2007.01.001
    Venelinov, Tony I. ; Beattie, John H. ; Dainty, Jack R. ; Hollands, Wendy J. ; Fairweather-Tait, Susan J. ; Harvey, Linda J. / Stable isotope pilot study of exchangeable copper kinetics in human blood plasma. In: Journal of Trace Elements in Medicine and Biology. 2007 ; Vol. 21, No. 2. pp. 138-140.
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    AU - Fairweather-Tait, Susan J.

    AU - Harvey, Linda J.

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