Stable isotope pilot study of exchangeable copper kinetics in human blood plasma

Tony I. Venelinov; John H. Beattie; Jack R. Dainty; Wendy J. Hollands; Susan J. Fairweather-Tait; Linda J. Harvey

doi:10.1016/j.jtemb.2007.01.001

Stable isotope pilot study of exchangeable copper kinetics in human blood plasma

Tony I. Venelinov, John H. Beattie, Jack R. Dainty, Wendy J. Hollands, Susan J. Fairweather-Tait, Linda J. Harvey

The Rowett Institute of Nutrition and Health

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

To develop further our understanding of initial dietary copper metabolism, a method has been developed to separate plasma copper that is bound to albumin, from that bound to ceruloplasmin. This method has been tested using plasma samples from a pilot study involving six human volunteers who consumed 3 mg oral doses of the stable isotope Cu-65 and gave blood samples at timed intervals up to 7 days. The results suggest that this method can be used to monitor dynamic fluctuations in newly absorbed copper over a short time frame. (C) 2007 Elsevier GmbH. All rights reserved.

Original language	English
Pages (from-to)	138-140
Number of pages	3
Journal	Journal of Trace Elements in Medicine and Biology
Volume	21
Issue number	2
DOIs	https://doi.org/10.1016/j.jtemb.2007.01.001
Publication status	Published - Jun 2007

Keywords

exchangeable copper
copper metabolism
dialysis-chelex
isotope ratio
ICP-MS
absorption

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10.1016/j.jtemb.2007.01.001

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title = "Stable isotope pilot study of exchangeable copper kinetics in human blood plasma",

abstract = "To develop further our understanding of initial dietary copper metabolism, a method has been developed to separate plasma copper that is bound to albumin, from that bound to ceruloplasmin. This method has been tested using plasma samples from a pilot study involving six human volunteers who consumed 3 mg oral doses of the stable isotope Cu-65 and gave blood samples at timed intervals up to 7 days. The results suggest that this method can be used to monitor dynamic fluctuations in newly absorbed copper over a short time frame. (C) 2007 Elsevier GmbH. All rights reserved.",

keywords = "exchangeable copper, copper metabolism, dialysis-chelex, isotope ratio, ICP-MS, absorption",

author = "Venelinov, {Tony I.} and Beattie, {John H.} and Dainty, {Jack R.} and Hollands, {Wendy J.} and Fairweather-Tait, {Susan J.} and Harvey, {Linda J.}",

year = "2007",

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language = "English",

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T1 - Stable isotope pilot study of exchangeable copper kinetics in human blood plasma

AU - Venelinov, Tony I.

AU - Beattie, John H.

AU - Dainty, Jack R.

AU - Hollands, Wendy J.

AU - Fairweather-Tait, Susan J.

AU - Harvey, Linda J.

PY - 2007/6

Y1 - 2007/6

N2 - To develop further our understanding of initial dietary copper metabolism, a method has been developed to separate plasma copper that is bound to albumin, from that bound to ceruloplasmin. This method has been tested using plasma samples from a pilot study involving six human volunteers who consumed 3 mg oral doses of the stable isotope Cu-65 and gave blood samples at timed intervals up to 7 days. The results suggest that this method can be used to monitor dynamic fluctuations in newly absorbed copper over a short time frame. (C) 2007 Elsevier GmbH. All rights reserved.

AB - To develop further our understanding of initial dietary copper metabolism, a method has been developed to separate plasma copper that is bound to albumin, from that bound to ceruloplasmin. This method has been tested using plasma samples from a pilot study involving six human volunteers who consumed 3 mg oral doses of the stable isotope Cu-65 and gave blood samples at timed intervals up to 7 days. The results suggest that this method can be used to monitor dynamic fluctuations in newly absorbed copper over a short time frame. (C) 2007 Elsevier GmbH. All rights reserved.

KW - exchangeable copper

KW - copper metabolism

KW - dialysis-chelex

KW - isotope ratio

KW - ICP-MS

KW - absorption

U2 - 10.1016/j.jtemb.2007.01.001

DO - 10.1016/j.jtemb.2007.01.001

M3 - Article

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SP - 138

EP - 140

JO - Journal of Trace Elements in Medicine and Biology

JF - Journal of Trace Elements in Medicine and Biology

IS - 2

ER -

Stable isotope pilot study of exchangeable copper kinetics in human blood plasma

Abstract

Keywords

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