Statins as emerging treatments for asthma and chronic obstructive pulmonary disease

Research output: Contribution to journalArticle

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Abstract

Asthma and chronic obstructive pulmonary disease (COPD) represent increasingly common respiratory conditions with a clear unmet need for more effective and safer therapy. Airway inflammation is key to both asthma pathogenesis and exacerbation of symptoms in COPD. Several lines of evidence are now emerging, demonstrasting that, in addition to their established effectiveness in the treatment of atherosclerotic disease, statins also exhibit anti-inflammatory properties, which may be of relevance for the treatment of chronic lung disease, including asthma and COPD. This review will examine the diverse in vitro and in vivo anti-inflammatory properties of statins and consider the available evidence that statins represent novel therapeutic interventions for asthma and COPD.
Original languageEnglish
Pages (from-to)329-335
Number of pages7
JournalExpert Review of Respiratory Medicine
Volume2
Issue number3
DOIs
Publication statusPublished - 1 Jun 2008

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Hydroxymethylglutaryl-CoA Reductase Inhibitors
Chronic Obstructive Pulmonary Disease
Asthma
Anti-Inflammatory Agents
Lung Diseases
Chronic Disease
Inflammation
Therapeutics

Cite this

Statins as emerging treatments for asthma and chronic obstructive pulmonary disease. / Walsh, Garry Michael.

In: Expert Review of Respiratory Medicine, Vol. 2, No. 3, 01.06.2008, p. 329-335.

Research output: Contribution to journalArticle

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