Stem cell niches in mammals

Thimios A. Mitsiadis, Ornella Barrandon, Ariane Rochat, Yann Barrandon, Cosimo De Bari

Research output: Contribution to journalArticle

160 Citations (Scopus)

Abstract

Stem cells safeguard tissue homeostasis and guarantee tissue repair throughout life. The decision between self-renewal and differentiation is influenced by a specialized microenvironment called stem cell niche. Physical and molecular interactions with niche cells and orientation of the cleavage plane during stem cell mitosis control the balance between symmetric and asymmetric division of stem cells. Here we highlight recent progress made on the anatomical and molecular characterization of mammalian stem cell niches, focusing particularly on bone marrow, tooth and hair follicle. The knowledge of the regulation of stem cells within their niches in health and disease will be instrumental to develop novel therapies that target stem cell niches to achieve tissue repair and re-establish tissue homeostasis.
Original languageEnglish
Pages (from-to)3377-3385
Number of pages9
JournalExperimental Cell Research
Volume313
Issue number16
Early online date2 Aug 2007
DOIs
Publication statusPublished - 1 Oct 2007

Fingerprint

Stem Cell Niche
Mammals
Stem Cells
Homeostasis
Asymmetric Cell Division
Hair Follicle
Mitosis
Tooth
Bone Marrow
Health

Keywords

  • animals
  • bone marrow cells
  • genetic variation
  • hair follicle
  • incisor
  • mammals
  • stem cells
  • tooth
  • hair
  • bone
  • notch signaling
  • niches

Cite this

Mitsiadis, T. A., Barrandon, O., Rochat, A., Barrandon, Y., & De Bari, C. (2007). Stem cell niches in mammals. Experimental Cell Research, 313(16), 3377-3385. https://doi.org/10.1016/j.yexcr.2007.07.027

Stem cell niches in mammals. / Mitsiadis, Thimios A.; Barrandon, Ornella; Rochat, Ariane; Barrandon, Yann; De Bari, Cosimo.

In: Experimental Cell Research, Vol. 313, No. 16, 01.10.2007, p. 3377-3385.

Research output: Contribution to journalArticle

Mitsiadis, TA, Barrandon, O, Rochat, A, Barrandon, Y & De Bari, C 2007, 'Stem cell niches in mammals' Experimental Cell Research, vol. 313, no. 16, pp. 3377-3385. https://doi.org/10.1016/j.yexcr.2007.07.027
Mitsiadis TA, Barrandon O, Rochat A, Barrandon Y, De Bari C. Stem cell niches in mammals. Experimental Cell Research. 2007 Oct 1;313(16):3377-3385. https://doi.org/10.1016/j.yexcr.2007.07.027
Mitsiadis, Thimios A. ; Barrandon, Ornella ; Rochat, Ariane ; Barrandon, Yann ; De Bari, Cosimo. / Stem cell niches in mammals. In: Experimental Cell Research. 2007 ; Vol. 313, No. 16. pp. 3377-3385.
@article{d68ed5d10a8149dc9b3fca52b952f872,
title = "Stem cell niches in mammals",
abstract = "Stem cells safeguard tissue homeostasis and guarantee tissue repair throughout life. The decision between self-renewal and differentiation is influenced by a specialized microenvironment called stem cell niche. Physical and molecular interactions with niche cells and orientation of the cleavage plane during stem cell mitosis control the balance between symmetric and asymmetric division of stem cells. Here we highlight recent progress made on the anatomical and molecular characterization of mammalian stem cell niches, focusing particularly on bone marrow, tooth and hair follicle. The knowledge of the regulation of stem cells within their niches in health and disease will be instrumental to develop novel therapies that target stem cell niches to achieve tissue repair and re-establish tissue homeostasis.",
keywords = "animals, bone marrow cells, genetic variation, hair follicle, incisor, mammals, stem cells, tooth, hair , bone, notch signaling, niches",
author = "Mitsiadis, {Thimios A.} and Ornella Barrandon and Ariane Rochat and Yann Barrandon and {De Bari}, Cosimo",
year = "2007",
month = "10",
day = "1",
doi = "10.1016/j.yexcr.2007.07.027",
language = "English",
volume = "313",
pages = "3377--3385",
journal = "Experimental Cell Research",
issn = "0014-4827",
publisher = "Academic Press Inc.",
number = "16",

}

TY - JOUR

T1 - Stem cell niches in mammals

AU - Mitsiadis, Thimios A.

AU - Barrandon, Ornella

AU - Rochat, Ariane

AU - Barrandon, Yann

AU - De Bari, Cosimo

PY - 2007/10/1

Y1 - 2007/10/1

N2 - Stem cells safeguard tissue homeostasis and guarantee tissue repair throughout life. The decision between self-renewal and differentiation is influenced by a specialized microenvironment called stem cell niche. Physical and molecular interactions with niche cells and orientation of the cleavage plane during stem cell mitosis control the balance between symmetric and asymmetric division of stem cells. Here we highlight recent progress made on the anatomical and molecular characterization of mammalian stem cell niches, focusing particularly on bone marrow, tooth and hair follicle. The knowledge of the regulation of stem cells within their niches in health and disease will be instrumental to develop novel therapies that target stem cell niches to achieve tissue repair and re-establish tissue homeostasis.

AB - Stem cells safeguard tissue homeostasis and guarantee tissue repair throughout life. The decision between self-renewal and differentiation is influenced by a specialized microenvironment called stem cell niche. Physical and molecular interactions with niche cells and orientation of the cleavage plane during stem cell mitosis control the balance between symmetric and asymmetric division of stem cells. Here we highlight recent progress made on the anatomical and molecular characterization of mammalian stem cell niches, focusing particularly on bone marrow, tooth and hair follicle. The knowledge of the regulation of stem cells within their niches in health and disease will be instrumental to develop novel therapies that target stem cell niches to achieve tissue repair and re-establish tissue homeostasis.

KW - animals

KW - bone marrow cells

KW - genetic variation

KW - hair follicle

KW - incisor

KW - mammals

KW - stem cells

KW - tooth

KW - hair

KW - bone

KW - notch signaling

KW - niches

U2 - 10.1016/j.yexcr.2007.07.027

DO - 10.1016/j.yexcr.2007.07.027

M3 - Article

VL - 313

SP - 3377

EP - 3385

JO - Experimental Cell Research

JF - Experimental Cell Research

SN - 0014-4827

IS - 16

ER -