TY - JOUR
T1 - Stratified medicine approaches for the treatment of musculoskeletal disorders
AU - Hocking, Lynne J
AU - Rivadeneira, Fernando
N1 - Copyright © 2014 Elsevier Ltd. All rights reserved.
Acknowledgements
The work of LJH in this area is funded by Arthritis Research UK and the Paget's Association UK. FR is funded by the Netherlands Scientific Organization ProjectNWO-ZonMW VIDI 016.136.367.
PY - 2014/6
Y1 - 2014/6
N2 - Stratified medicine approaches for the treatment of musculoskeletal disorders offer opportunities to effectively target interventions to those individuals who will gain most benefit from them and minimise adverse side effects. Such approaches have been the 'holy grail' of a variety of research fields spanning epidemiological, (epi)genetic, transcriptomic, proteomic and imaging biomarkers that predict disease diagnosis, prognosis or response to treatment. In this review, we highlight the successes and opportunities for stratified medicine approaches across a range of musculoskeletal disorders, with a focus on genetic risk factors, since these are the most stable across the lifetime of each individual.
AB - Stratified medicine approaches for the treatment of musculoskeletal disorders offer opportunities to effectively target interventions to those individuals who will gain most benefit from them and minimise adverse side effects. Such approaches have been the 'holy grail' of a variety of research fields spanning epidemiological, (epi)genetic, transcriptomic, proteomic and imaging biomarkers that predict disease diagnosis, prognosis or response to treatment. In this review, we highlight the successes and opportunities for stratified medicine approaches across a range of musculoskeletal disorders, with a focus on genetic risk factors, since these are the most stable across the lifetime of each individual.
U2 - 10.1016/j.coph.2014.05.003
DO - 10.1016/j.coph.2014.05.003
M3 - Article
C2 - 24880767
VL - 16
SP - 127
EP - 132
JO - Current Opinion in Pharmacology
JF - Current Opinion in Pharmacology
SN - 1471-4892
ER -