Stress Adaptation

Alistair J. P. Brown, Leah E. Cowen, Antonio Di Pietro, Janet Quinn

Research output: Contribution to journalArticle

7 Citations (Scopus)
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Abstract

Fungal species display an extraordinarily diverse range of lifestyles. Nevertheless, the survival of each species depends on its ability to sense and respond to changes in its natural environment. Environmental changes such as fluctuations in temperature, water balance or pH, or exposure to chemical insults such as reactive oxygen and nitrogen species exert stresses that perturb cellular homeostasis and cause molecular damage to the fungal cell. Consequently, fungi have evolved mechanisms to repair this damage, detoxify chemical insults, and restore cellular homeostasis. Most stresses are fundamental in nature, and consequently, there has been significant evolutionary conservation in the nature of the resultant responses across the fungal kingdom and beyond. For example, heat shock generally induces the synthesis of chaperones that promote protein refolding, antioxidants are generally synthesized in response to an oxidative stress, and osmolyte levels are generally increased following a hyperosmotic shock. In this article we summarize the current understanding of these and other stress responses as well as the signaling pathways that regulate them in the fungi. Model yeasts such as Saccharomyces cerevisiae are compared with filamentous fungi, as well as with pathogens of plants and humans. We also discuss current challenges associated with defining the dynamics of stress responses and with the elaboration of fungal stress adaptation under conditions that reflect natural environments in which fungal cells may be exposed to different types of stresses, either sequentially or simultaneously.
Original languageEnglish
Pages (from-to)1-23
Number of pages23
JournalMicrobiology spectrum
Volume5
Issue number4
DOIs
Publication statusPublished - 14 Jul 2017

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Fungi
homeostasis
fungus
Shock
Homeostasis
Protein Refolding
Reactive Nitrogen Species
damage
Aptitude
heat shock
lifestyle
antioxidant
repair
yeast
Saccharomyces cerevisiae
Life Style
water budget
Reactive Oxygen Species
environmental change
Oxidative Stress

Cite this

Brown, A. J. P., Cowen, L. E., Di Pietro, A., & Quinn, J. (2017). Stress Adaptation. Microbiology spectrum, 5(4), 1-23. https://doi.org/10.1128/microbiolspec.FUNK-0048-2016

Stress Adaptation. / Brown, Alistair J. P.; Cowen, Leah E. ; Di Pietro, Antonio; Quinn, Janet.

In: Microbiology spectrum, Vol. 5, No. 4, 14.07.2017, p. 1-23.

Research output: Contribution to journalArticle

Brown, AJP, Cowen, LE, Di Pietro, A & Quinn, J 2017, 'Stress Adaptation', Microbiology spectrum, vol. 5, no. 4, pp. 1-23. https://doi.org/10.1128/microbiolspec.FUNK-0048-2016
Brown AJP, Cowen LE, Di Pietro A, Quinn J. Stress Adaptation. Microbiology spectrum. 2017 Jul 14;5(4):1-23. https://doi.org/10.1128/microbiolspec.FUNK-0048-2016
Brown, Alistair J. P. ; Cowen, Leah E. ; Di Pietro, Antonio ; Quinn, Janet. / Stress Adaptation. In: Microbiology spectrum. 2017 ; Vol. 5, No. 4. pp. 1-23.
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