STROKOG (stroke and cognition consortium): An international consortium to examine the epidemiology, diagnosis, and treatment of neurocognitive disorders in relation to cerebrovascular disease

Perminder S. Sachdev* (Corresponding Author), Jessica W. Lo, John D. Crawford, Lisa Mellon, Anna Hickey, David Williams, Regis Bordet, Anne-Marie Mendyk, Patrick Gele, Dominique Deplanque, Hee-Joon Bae, Jae-Sung Lim, Amy Brodtmann, Emilio Werden, Toby Cumming, Sebastian Kohler, Frans R. J. Verhey, Yan-Hong Dong, Hui Hui Tan, Christopher ChenXu Xin, Raj N. Kalaria, Louise M. Allan, Rufus O. Akinyemi, Adesola Ogunniyi, Aleksandra Klimkowicz-Mrowiec, Martin Dichgans, Frank A. Wollenweber, Vera Zietemann, Michael Hoffmann, David W. Desmond, Thomas Linden, Christian Blomstrand, Bjorn Fagerberg, Ingmar Skoog, Olivier Godefroy, Melanie Barbay, Martine Roussel, Byung-Chul Lee, Kyung-Ho Yu, Joanna Wardlaw, Stephen J. Makin, Fergus N. Doubal, Francesca M. Chappell, Velandai K. Srikanth, Amanda G. Thrift, Geoffrey A. Donnan, Nagaendran Kandiah, Russell J. Chander, Xuling Lin, Charlotte Cordonnier, Solene Moulin, Costanza Rossi, Behnam Sabayan, David J. Stott, J. Wouter Jukema, Susanna Melkas, Hanna Jokinen, Timo Erkinjuntti, Vincent C. T. Mok, Adrian Wong, Bonnie Y. K. Lam, Didier Leys, Hilde Henon, Stephanie Bombois, Darren M. Lipnicki, Nicole A. Kochan

*Corresponding author for this work

Research output: Contribution to journalArticle

18 Citations (Scopus)
1 Downloads (Pure)

Abstract

INTRODUCTION: The Stroke and Cognition consortium (STROKOG) aims to facilitate a better understanding of the determinants of vascular contributions to cognitive disorders and help improve the diagnosis and treatment of vascular cognitive disorders (VCD). METHODS: Longitudinal studies with >/=75 participants who had suffered or were at risk of stroke or TIA and which evaluated cognitive function were invited to join STROKOG. The consortium will facilitate projects investigating rates and patterns of cognitive decline, risk factors for VCD, and biomarkers of vascular dementia. RESULTS: Currently, STROKOG includes 25 (21 published) studies, with 12,092 participants from five continents. The duration of follow-up ranges from 3 months to 21 years. DISCUSSION: Although data harmonization will be a key challenge, STROKOG is in a unique position to reuse and combine international cohort data and fully explore patient level characteristics and outcomes. STROKOG could potentially transform our understanding of VCD and have a worldwide impact on promoting better vascular cognitive outcomes.
Original languageEnglish
Pages (from-to)11-23
Number of pages13
JournalAlzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
Volume7
Early online date18 Nov 2016
DOIs
Publication statusPublished - 2017

Keywords

  • Cohort studies
  • Vascular dementia
  • Post-stroke dementia
  • Vascular cognitive disorder
  • Small vessel disease
  • Data harmonization
  • International consortium

Fingerprint Dive into the research topics of 'STROKOG (stroke and cognition consortium): An international consortium to examine the epidemiology, diagnosis, and treatment of neurocognitive disorders in relation to cerebrovascular disease'. Together they form a unique fingerprint.

  • Cite this

    Sachdev, P. S., Lo, J. W., Crawford, J. D., Mellon, L., Hickey, A., Williams, D., Bordet, R., Mendyk, A-M., Gele, P., Deplanque, D., Bae, H-J., Lim, J-S., Brodtmann, A., Werden, E., Cumming, T., Kohler, S., Verhey, F. R. J., Dong, Y-H., Tan, H. H., ... Kochan, N. A. (2017). STROKOG (stroke and cognition consortium): An international consortium to examine the epidemiology, diagnosis, and treatment of neurocognitive disorders in relation to cerebrovascular disease. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 7, 11-23. https://doi.org/10.1016/j.dadm.2016.10.006