Structural and functional alterations in the androgen receptor in spinal bulbar muscular atrophy

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Abstract

The androgen receptor is a member of the nuclear receptor superfamily, and regulates gene expression in response to the steroid hormones testosterone and dihydrotestosterone. Mutations in the receptor have been correlated with a diverse range of clinical conditions, including androgen insensitivity, prostate cancer and spinal bulbar muscular atrophy, a neuromuscular degenerative condition. The latter is caused by expansion of a pol?;glutamine repeat within the N-terminal domain of the receptor. Thus the androgen receptor is one of a growing number of neurodegenerative disease-associated proteins, including huntingtin (Huntington's disease), ataxin-1 (spinocerebellar ataxia, type I)and ataxin-3 (spinocerebellar ataxia, type 3), which show expansion of CAG triplet repeats. Although widely studied, the functions of huntingtin, ataxin-1 and ataxin-3 remain unknown. The androgen receptor, which has a well-recognized function in gene regulation, provides a unique opportunity to investigate the functional significance of poly(amino acid) repeats in normal and disease states.

Original languageEnglish
Pages (from-to)222-227
Number of pages5
JournalBiochemical Society Transactions
Volume29
Issue numberPt 2
DOIs
Publication statusPublished - 2001

Keywords

  • aggregation
  • androgen action
  • gene regulation
  • protein conformation
  • polyglutamine repeat
  • N-TERMINAL DOMAIN
  • POLYGLUTAMINE TRACT
  • AGGREGATE FORMATION
  • PROSTATE-CANCER
  • TRANSCRIPTIONAL ACTIVATION
  • TRANSACTIVATION FUNCTION
  • EXPANDED POLYGLUTAMINE
  • TRINUCLEOTIDE REPEATS
  • KENNEDYS-DISEASE
  • MALE-INFERTILITY

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