Structural brain complexity and cognitive decline in late life: A longitudinal study in the Aberdeen 1936 Birth Cohort

Anca-Larisa Sandu-Giuraniuc, Roger T Staff, Chris J McNeil, Nazahah Mustafa, Trevor Ahearn, Lawrence J Whalley, Alison D Murray

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Abstract

Brain morphology and cognitive ability change with age. Gray and white matter volumes decrease markedly by the 7th decade of life when cognitive decreases first become readily detectable. As a consequence, the shape complexity of the cortical mantle may also change. The purposes of this study are to examine changes over a five year period in brain structural complexity in late life, and to investigate cognitive correlates of any changes. Brain magnetic resonance images at 1.5Tesla were acquired from the Aberdeen 1936 Birth Cohort at about ages 68years (243 participants) and 73years (148 participants returned). Measures of brain complexity were extracted using Fractal Dimension (FD) and calculated using the box-counting method. White matter complexity, brain volumes and cognitive performance were measured at both 68 and 73years. Childhood ability was measured at age 11 using the Moray House Test. FD and brain volume decrease significantly from age 68 to 73years. Using a multilevel linear modeling approach, we conclude that individual decreases in late life white matter complexity are not associated with differences in executive function but are linked to information processing speed, auditory-verbal learning, and reasoning in specific models-with adjustment for childhood mental ability. A significant association was found after adjustment for age, brain volume and childhood mental ability. Complexity of white matter is associated with higher fluid cognitive ability and, in a longitudinal study, predicts retention of cognitive ability within late life.

Original languageEnglish
Pages (from-to)558-563
Number of pages6
JournalNeuroimage
Volume100
Early online date30 Jun 2014
DOIs
Publication statusPublished - 15 Oct 2014

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Keywords

  • cortical complexity
  • fractal dimension
  • white matter
  • cognition
  • aging
  • brain magnetic resonance imaging

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