Structural connectivity modifications in the brain of selected patients with tumour after its removal by surgery (a case study)

E.  Sayari; Evandro G. Seifert; F. E.  Cruziniani; Enrique C. Gabrick; Kelly C. Iarosz; Jose D. Szezech Jr; Murilo Baptista; I. L. Caldas; Antonio M. Batista

doi:10.1016/j.physa.2023.128849

Structural connectivity modifications in the brain of selected patients with tumour after its removal by surgery (a case study)

E. Sayari^* (Corresponding Author), Evandro G. Seifert, F. E. Cruziniani, Enrique C. Gabrick, Kelly C. Iarosz, Jose D. Szezech Jr, Murilo Baptista, I. L. Caldas, Antonio M. Batista

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

The brain is a complex organ that plays an important role in the control of
most functions of the body, such as awareness, thoughts, sensations, movements, speech, and memory. A tumour formed in the brain can affect its
ability to accurately and properly perform such functions. In this work,
we use two brains with malignant tumours of different sizes before and after surgery. To identify the brain structural topology, we analyse different
networks with various configurations and use diagnostic tools to match the
network topologies generated by simulations with those obtained from the
data. Our results show that the Newman-Watts small-world network best reproduces the topology from the patients with small and large tumours before
surgery. Considering two analysed brains, our outcomes suggest that surgery
can alter the brain topology from small-world to extended Barab´asi-Albert
scale-free.

Original language	English
Article number	128849
Number of pages	15
Journal	Physica. A, Statistical Mechanics and its Applications
Volume	623
Early online date	23 May 2023
DOIs	https://doi.org/10.1016/j.physa.2023.128849
Publication status	Published - 1 Aug 2023

Bibliographical note

Acknowledgments
This study was possible by partial financial support from the following agencies: Funda¸c˜ao Arauc´aria, Brazilian National Council for Scientific and Technological Development (CNPq), and Coordination for the Improvement of Higher Education Personnel (CAPES). S˜ao Paulo Research Foundation (FAPESP 2018/03211-6, 2022/13761-9). We thank 105 Group Science (www.105groupscience.com).

Keywords

Complex system
Brain tumor
Structural connectivity matrix
Graph theory

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Sayari, E., Seifert, E. G., Cruziniani, F. E., Gabrick, E. C., Iarosz, K. C., Szezech Jr, J. D., Baptista, M., Caldas, I. L., & Batista, A. M. (2023). Structural connectivity modifications in the brain of selected patients with tumour after its removal by surgery (a case study). Physica. A, Statistical Mechanics and its Applications, 623, Article 128849. https://doi.org/10.1016/j.physa.2023.128849

Sayari, E, Seifert, EG, Cruziniani, FE, Gabrick, EC, Iarosz, KC, Szezech Jr, JD, Baptista, M, Caldas, IL & Batista, AM 2023, 'Structural connectivity modifications in the brain of selected patients with tumour after its removal by surgery (a case study)', Physica. A, Statistical Mechanics and its Applications, vol. 623, 128849. https://doi.org/10.1016/j.physa.2023.128849

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abstract = "The brain is a complex organ that plays an important role in the control ofmost functions of the body, such as awareness, thoughts, sensations, movements, speech, and memory. A tumour formed in the brain can affect itsability to accurately and properly perform such functions. In this work,we use two brains with malignant tumours of different sizes before and after surgery. To identify the brain structural topology, we analyse differentnetworks with various configurations and use diagnostic tools to match thenetwork topologies generated by simulations with those obtained from thedata. Our results show that the Newman-Watts small-world network best reproduces the topology from the patients with small and large tumours beforesurgery. Considering two analysed brains, our outcomes suggest that surgerycan alter the brain topology from small-world to extended Barab´asi-Albertscale-free.",

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note = "Acknowledgments This study was possible by partial financial support from the following agencies: Funda¸c˜ao Arauc´aria, Brazilian National Council for Scientific and Technological Development (CNPq), and Coordination for the Improvement of Higher Education Personnel (CAPES). S˜ao Paulo Research Foundation (FAPESP 2018/03211-6, 2022/13761-9). We thank 105 Group Science (www.105groupscience.com).",

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AU - Batista, Antonio M.

N1 - Acknowledgments This study was possible by partial financial support from the following agencies: Funda¸c˜ao Arauc´aria, Brazilian National Council for Scientific and Technological Development (CNPq), and Coordination for the Improvement of Higher Education Personnel (CAPES). S˜ao Paulo Research Foundation (FAPESP 2018/03211-6, 2022/13761-9). We thank 105 Group Science (www.105groupscience.com).

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N2 - The brain is a complex organ that plays an important role in the control ofmost functions of the body, such as awareness, thoughts, sensations, movements, speech, and memory. A tumour formed in the brain can affect itsability to accurately and properly perform such functions. In this work,we use two brains with malignant tumours of different sizes before and after surgery. To identify the brain structural topology, we analyse differentnetworks with various configurations and use diagnostic tools to match thenetwork topologies generated by simulations with those obtained from thedata. Our results show that the Newman-Watts small-world network best reproduces the topology from the patients with small and large tumours beforesurgery. Considering two analysed brains, our outcomes suggest that surgerycan alter the brain topology from small-world to extended Barab´asi-Albertscale-free.

AB - The brain is a complex organ that plays an important role in the control ofmost functions of the body, such as awareness, thoughts, sensations, movements, speech, and memory. A tumour formed in the brain can affect itsability to accurately and properly perform such functions. In this work,we use two brains with malignant tumours of different sizes before and after surgery. To identify the brain structural topology, we analyse differentnetworks with various configurations and use diagnostic tools to match thenetwork topologies generated by simulations with those obtained from thedata. Our results show that the Newman-Watts small-world network best reproduces the topology from the patients with small and large tumours beforesurgery. Considering two analysed brains, our outcomes suggest that surgerycan alter the brain topology from small-world to extended Barab´asi-Albertscale-free.

KW - Complex system

KW - Brain tumor

KW - Structural connectivity matrix

KW - Graph theory

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DO - 10.1016/j.physa.2023.128849

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JO - Physica. A, Statistical Mechanics and its Applications

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ER -

Structural connectivity modifications in the brain of selected patients with tumour after its removal by surgery (a case study)

Abstract

Bibliographical note

Keywords

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