Abstract
The crystal and molecular structures of three racemic erythro-(R*, S*)-(+/-)-alpha-2-piperidiny1-2,8-bis(trifluoromethyl)-4-quinolinemethanol n-nitrobenzoates, n = 2, 3, and 4, are described. The cations uniformly adopt an L-shaped geometry with protonation leading to a piperidin-1-ium ring in each case. A non-planar arrangement is found for the anion in (1; n = 2), owing to steric congestion, but almost planar arrangements are found in each of the anions in (2; n = 3) and (3; n = 4). Supramolecular chains are found in each of the crystal structures but these are sustained by different hydrogen bonding synthons. More efficient crystal packing in (3; n = 4) is correlated with a single synthon as opposed to two distinct synthons in each of (1; n = 2) and (2; n = 3). Crystal data for (1; n = 2): monoclinic, P2(1)/n, a = 13.2144(6), b = 8.1028(2), c = 22.9724(9) angstrom, beta = 105.919(1)degrees, V = 2365.41(15) angstrom(3), Z = 4, R = 0.053. Crystal data for (2; n = 3): monoclinic, P2(1)/n, a = 6.8389(2), b = 12.8432(4), c = 26.7910(9) angstrom, beta = 90.868(2)degrees, V = 2352.87(13) angstrom(3), Z = 4, R = 0.044. Crystal data for (3; n = 4): monoclinic, P2(1)/n, a = 16.9854(8), b = 6.5069(2), c = 20.2083(9) angstrom, beta = 92.116(2)degrees, V = 2231.94(16) angstrom(3), = 4, R = 0.065.
Original language | English |
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Pages (from-to) | 68-77 |
Number of pages | 10 |
Journal | Zeitschrift für Kristallographie |
Volume | 226 |
Issue number | 1 |
DOIs | |
Publication status | Published - Jan 2011 |
Keywords
- mefloquine
- organic salt
- conformation
- hydrogen bonding
- x-ray diffraction
- single crystal structure analysis
- crystal-structure
- hydrochloride
- fluorine
- malaria
- drug