Structure-based finite strain modelling of the human left ventricle in diastole

H M Wang, H Gao, X Y Luo, C Berry, B E Griffith, R W Ogden, T J Wang

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Abstract

Finite strain analyses of the left ventricle provide important information on heart function and have the potential to provide insights into the biomechanics of myocardial contractility in health and disease. Systolic dysfunction is the most common cause of heart failure; however, abnormalities of diastolic function also contribute to heart failure, and are associated with conditions including left ventricular hypertrophy and diabetes. The clinical significance of diastolic abnormalities is less well understood than systolic dysfunction, and specific treatments are presently lacking. To obtain qualitative and quantitative information on heart function in diastole, we develop a three-dimensional computational model of the human left ventricle that is derived from noninvasive imaging data. This anatomically realistic model has a rule-based fibre structure and a structure-based constitutive model. We investigate the sensitivity of this comprehensive model to small changes in the constitutive parameters and to changes in the fibre distribution. We make extensive comparisons between this model and similar models that employ different constitutive models, and we demonstrate qualitative and quantitative differences in stress and strain distributions for the different constitutive models. We also provide an initial validation of our model through comparisons to experimental data on stress and strain distributions in the left ventricle. Copyright (C) 2012 John Wiley & Sons, Ltd.

Original languageEnglish
Pages (from-to)83-103
Number of pages21
JournalInternational journal for numerical methods in biomedical engineering
Volume29
Issue number1
Early online date27 Jun 2012
DOIs
Publication statusPublished - Jan 2013

Keywords

  • left ventricle in diastole
  • constitutive law
  • fibre structure
  • finite element methods
  • nonlinear finite strain
  • MRI

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