Suboptimal persistence with inhaled corticosteroid monotherapy among children with persistent asthma in the UK

Qiaoyi Zhang, Stephanie Taylor, Vasilisa Sazonov, Mike Thomas, David Price

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

BACKGROUND: Long-term studies indicate that adherence to asthma controller therapy decreases over time, and persistence with therapy may be poor. METHODS: This primary care database study assessed persistence with therapy over one year after first prescription of inhaled corticosteroid (ICS) for children aged 2-14 years with a diagnosis of asthma. Children with intermittent asthma were excluded. Discontinuation was defined as no ICS prescription during the last three months of the follow-up year. RESULTS: 2220 of 7375 children receiving a first prescription for ICS had persistent asthma. Mean (±SD) age was 7.3 (±3.8) years; 59.5% were male. A total of 745 (33.6%) continued initial ICS, 133 (6.0%) received add-on therapy, 150 (6.8%) switched to another asthma therapy, and 1192 (53.7%) discontinued therapy. These percentages were similar for children aged 2-5 or 6-14 years. CONCLUSION: Persistence with first-time ICS monotherapy is poor among children with persistent asthma.
Original languageEnglish
Pages (from-to)97-101
Number of pages5
JournalPrimary Care Respiratory Journal
Volume20
Issue number1
Early online date7 Oct 2010
DOIs
Publication statusPublished - Mar 2011

Fingerprint

Adrenal Cortex Hormones
Asthma
Prescriptions
Therapeutics
Primary Health Care
Databases

Keywords

  • asthma
  • inhaled corticosteroid
  • paediatrics
  • observational
  • persistence
  • therapy

Cite this

Suboptimal persistence with inhaled corticosteroid monotherapy among children with persistent asthma in the UK. / Zhang, Qiaoyi; Taylor, Stephanie; Sazonov, Vasilisa ; Thomas, Mike; Price, David.

In: Primary Care Respiratory Journal, Vol. 20, No. 1, 03.2011, p. 97-101.

Research output: Contribution to journalArticle

Zhang, Qiaoyi ; Taylor, Stephanie ; Sazonov, Vasilisa ; Thomas, Mike ; Price, David. / Suboptimal persistence with inhaled corticosteroid monotherapy among children with persistent asthma in the UK. In: Primary Care Respiratory Journal. 2011 ; Vol. 20, No. 1. pp. 97-101.
@article{ac544ca4717343acb9ec46ed7ec8a1fc,
title = "Suboptimal persistence with inhaled corticosteroid monotherapy among children with persistent asthma in the UK",
abstract = "BACKGROUND: Long-term studies indicate that adherence to asthma controller therapy decreases over time, and persistence with therapy may be poor. METHODS: This primary care database study assessed persistence with therapy over one year after first prescription of inhaled corticosteroid (ICS) for children aged 2-14 years with a diagnosis of asthma. Children with intermittent asthma were excluded. Discontinuation was defined as no ICS prescription during the last three months of the follow-up year. RESULTS: 2220 of 7375 children receiving a first prescription for ICS had persistent asthma. Mean (±SD) age was 7.3 (±3.8) years; 59.5{\%} were male. A total of 745 (33.6{\%}) continued initial ICS, 133 (6.0{\%}) received add-on therapy, 150 (6.8{\%}) switched to another asthma therapy, and 1192 (53.7{\%}) discontinued therapy. These percentages were similar for children aged 2-5 or 6-14 years. CONCLUSION: Persistence with first-time ICS monotherapy is poor among children with persistent asthma.",
keywords = "asthma, inhaled corticosteroid, paediatrics, observational, persistence, therapy",
author = "Qiaoyi Zhang and Stephanie Taylor and Vasilisa Sazonov and Mike Thomas and David Price",
year = "2011",
month = "3",
doi = "10.4104/pcrj.2010.00061",
language = "English",
volume = "20",
pages = "97--101",
journal = "Primary Care Respiratory Journal",
issn = "1475-1534",
publisher = "Primary Care Respiratory Society UK",
number = "1",

}

TY - JOUR

T1 - Suboptimal persistence with inhaled corticosteroid monotherapy among children with persistent asthma in the UK

AU - Zhang, Qiaoyi

AU - Taylor, Stephanie

AU - Sazonov, Vasilisa

AU - Thomas, Mike

AU - Price, David

PY - 2011/3

Y1 - 2011/3

N2 - BACKGROUND: Long-term studies indicate that adherence to asthma controller therapy decreases over time, and persistence with therapy may be poor. METHODS: This primary care database study assessed persistence with therapy over one year after first prescription of inhaled corticosteroid (ICS) for children aged 2-14 years with a diagnosis of asthma. Children with intermittent asthma were excluded. Discontinuation was defined as no ICS prescription during the last three months of the follow-up year. RESULTS: 2220 of 7375 children receiving a first prescription for ICS had persistent asthma. Mean (±SD) age was 7.3 (±3.8) years; 59.5% were male. A total of 745 (33.6%) continued initial ICS, 133 (6.0%) received add-on therapy, 150 (6.8%) switched to another asthma therapy, and 1192 (53.7%) discontinued therapy. These percentages were similar for children aged 2-5 or 6-14 years. CONCLUSION: Persistence with first-time ICS monotherapy is poor among children with persistent asthma.

AB - BACKGROUND: Long-term studies indicate that adherence to asthma controller therapy decreases over time, and persistence with therapy may be poor. METHODS: This primary care database study assessed persistence with therapy over one year after first prescription of inhaled corticosteroid (ICS) for children aged 2-14 years with a diagnosis of asthma. Children with intermittent asthma were excluded. Discontinuation was defined as no ICS prescription during the last three months of the follow-up year. RESULTS: 2220 of 7375 children receiving a first prescription for ICS had persistent asthma. Mean (±SD) age was 7.3 (±3.8) years; 59.5% were male. A total of 745 (33.6%) continued initial ICS, 133 (6.0%) received add-on therapy, 150 (6.8%) switched to another asthma therapy, and 1192 (53.7%) discontinued therapy. These percentages were similar for children aged 2-5 or 6-14 years. CONCLUSION: Persistence with first-time ICS monotherapy is poor among children with persistent asthma.

KW - asthma

KW - inhaled corticosteroid

KW - paediatrics

KW - observational

KW - persistence

KW - therapy

U2 - 10.4104/pcrj.2010.00061

DO - 10.4104/pcrj.2010.00061

M3 - Article

VL - 20

SP - 97

EP - 101

JO - Primary Care Respiratory Journal

JF - Primary Care Respiratory Journal

SN - 1475-1534

IS - 1

ER -