Substance P selectively decreases paired pulse depression in the rat hippocampal slice

Kerrie N Wease, Stephen N Davies

Research output: Contribution to journalArticle

1 Citation (Scopus)
4 Downloads (Pure)

Abstract

Background Although being widespread in the hippocampus, the role tachykinins play in synaptic transmission is unclear. The effect of substance P on field potentials evoked by stimulation of the Schaffer collateral-commissural fibres and recorded from the CA1 region of the rat hippocampal slice were studied. Results Perfusion of substance P (8 μM) had no effect on the fEPSP or population spike. Substance P did however cause a selective reduction in the paired pulse depression of population spikes evoked by paired stimulation at interpulse intervals of 20–80 msec. A comparison of the actions of other tachykinin receptor agonists gave an order of potency of substance P > [β-Ala8]-neurokinin A (4–10) > senktide. The effect of substance P was reduced by the neurokinin-1 receptor antagonist SR140333, but not by the neurokinin-2 or neurokinin-3 receptor antagonists, MDL 29,913 or [Trp7, β-Ala8]-neurokinin A (4–10). Conclusion The order of potency of the agonists, and the effects of the antagonists, both indicate that the effect of substance P on paired pulse depression is mediated by neurokinin-1 receptors.
Original languageEnglish
Article number66
Number of pages8
JournalBMC Neuroscience
Volume6
DOIs
Publication statusPublished - 23 Nov 2005

Fingerprint

Substance P
Neurokinin A
Hippocampus
Neurokinin-3 Receptors
Neurokinin-1 Receptor Antagonists
Tachykinin Receptors
Neurokinin-1 Receptors
Hippocampal CA1 Region
Tachykinins
Evoked Potentials
Synaptic Transmission
Population

Cite this

Substance P selectively decreases paired pulse depression in the rat hippocampal slice. / Wease, Kerrie N; Davies, Stephen N.

In: BMC Neuroscience, Vol. 6, 66, 23.11.2005.

Research output: Contribution to journalArticle

@article{1a5244dc5817463fbd48a2c52b20b43d,
title = "Substance P selectively decreases paired pulse depression in the rat hippocampal slice",
abstract = "Background Although being widespread in the hippocampus, the role tachykinins play in synaptic transmission is unclear. The effect of substance P on field potentials evoked by stimulation of the Schaffer collateral-commissural fibres and recorded from the CA1 region of the rat hippocampal slice were studied. Results Perfusion of substance P (8 μM) had no effect on the fEPSP or population spike. Substance P did however cause a selective reduction in the paired pulse depression of population spikes evoked by paired stimulation at interpulse intervals of 20–80 msec. A comparison of the actions of other tachykinin receptor agonists gave an order of potency of substance P > [β-Ala8]-neurokinin A (4–10) > senktide. The effect of substance P was reduced by the neurokinin-1 receptor antagonist SR140333, but not by the neurokinin-2 or neurokinin-3 receptor antagonists, MDL 29,913 or [Trp7, β-Ala8]-neurokinin A (4–10). Conclusion The order of potency of the agonists, and the effects of the antagonists, both indicate that the effect of substance P on paired pulse depression is mediated by neurokinin-1 receptors.",
author = "Wease, {Kerrie N} and Davies, {Stephen N}",
year = "2005",
month = "11",
day = "23",
doi = "10.1186/1471-2202-6-66",
language = "English",
volume = "6",
journal = "BMC Neuroscience",
issn = "1471-2202",
publisher = "BioMed Central",

}

TY - JOUR

T1 - Substance P selectively decreases paired pulse depression in the rat hippocampal slice

AU - Wease, Kerrie N

AU - Davies, Stephen N

PY - 2005/11/23

Y1 - 2005/11/23

N2 - Background Although being widespread in the hippocampus, the role tachykinins play in synaptic transmission is unclear. The effect of substance P on field potentials evoked by stimulation of the Schaffer collateral-commissural fibres and recorded from the CA1 region of the rat hippocampal slice were studied. Results Perfusion of substance P (8 μM) had no effect on the fEPSP or population spike. Substance P did however cause a selective reduction in the paired pulse depression of population spikes evoked by paired stimulation at interpulse intervals of 20–80 msec. A comparison of the actions of other tachykinin receptor agonists gave an order of potency of substance P > [β-Ala8]-neurokinin A (4–10) > senktide. The effect of substance P was reduced by the neurokinin-1 receptor antagonist SR140333, but not by the neurokinin-2 or neurokinin-3 receptor antagonists, MDL 29,913 or [Trp7, β-Ala8]-neurokinin A (4–10). Conclusion The order of potency of the agonists, and the effects of the antagonists, both indicate that the effect of substance P on paired pulse depression is mediated by neurokinin-1 receptors.

AB - Background Although being widespread in the hippocampus, the role tachykinins play in synaptic transmission is unclear. The effect of substance P on field potentials evoked by stimulation of the Schaffer collateral-commissural fibres and recorded from the CA1 region of the rat hippocampal slice were studied. Results Perfusion of substance P (8 μM) had no effect on the fEPSP or population spike. Substance P did however cause a selective reduction in the paired pulse depression of population spikes evoked by paired stimulation at interpulse intervals of 20–80 msec. A comparison of the actions of other tachykinin receptor agonists gave an order of potency of substance P > [β-Ala8]-neurokinin A (4–10) > senktide. The effect of substance P was reduced by the neurokinin-1 receptor antagonist SR140333, but not by the neurokinin-2 or neurokinin-3 receptor antagonists, MDL 29,913 or [Trp7, β-Ala8]-neurokinin A (4–10). Conclusion The order of potency of the agonists, and the effects of the antagonists, both indicate that the effect of substance P on paired pulse depression is mediated by neurokinin-1 receptors.

U2 - 10.1186/1471-2202-6-66

DO - 10.1186/1471-2202-6-66

M3 - Article

VL - 6

JO - BMC Neuroscience

JF - BMC Neuroscience

SN - 1471-2202

M1 - 66

ER -