While there is a burgeoning interest in the effects of nutrition on systemic inflammatory diseases, how dietary macronutrient balance impacts local chronic inflammatory diseases in the mouth has been largely overlooked. Here, we used the Geometric Framework for Nutrition to test how the amounts of dietary macronutrients and their interactions, as well as carbohydrate type (starch vs sucrose vs resistant starch) influenced periodontitis-associated alveolar bone height in mice. Increasing intake of carbohydrates reduced alveolar bone height, while dietary protein had no effect. Whether carbohydrate came from sugar or starch did not influence the extent of alveolar bone height. In summary, the amount of carbohydrate in the diet modulated periodontitis-associated alveolar bone height independent of the source of carbohydrates.
Morimoto, J., Senior, A., Ruiz, K., Wali, J. A., Pulpitel, T., Solon-Biet, S. M., Cogger, V. C., Raubenheimer, D., Le Couteur, D. G., Simpson, S. J., & Eberhard, J. (2019). Sucrose and starch intake contribute to reduced alveolar bone height in a rodent model of naturally occurring periodontitis. PloS ONE, 14(3), . https://doi.org/10.1371/journal.pone.0212796, https://doi.org/10.5061/dryad.7c702sb