TY - JOUR
T1 - Sucrose and starch intake contribute to reduced alveolar bone height in a rodent model of naturally occurring periodontitis
AU - Morimoto, J.
AU - Senior, Alistair
AU - Ruiz, Kate
AU - Wali, Jibran A
AU - Pulpitel, Tamara
AU - Solon-Biet, Samantha M.
AU - Cogger, Victoria C.
AU - Raubenheimer, D.
AU - Le Couteur, David G.
AU - Simpson, Stephen J
AU - Eberhard, Joerg
N1 - Funding: This research project was funded in part by the Strategic Research Excellence Initiative 2020 (SREI2020), University of Sydney to JE and the University of Sydney HMR + Implementation Funding Grant to VC, DLC and SS.
PY - 2019/3/13
Y1 - 2019/3/13
N2 - While there is a burgeoning interest in the effects of nutrition on systemic inflammatory diseases, how dietary macronutrient balance impacts local chronic inflammatory diseases in the mouth has been largely overlooked. Here, we used the Geometric Framework for Nutrition to test how the amounts of dietary macronutrients and their interactions, as well as carbohydrate type (starch vs sucrose vs resistant starch) influenced periodontitis-associated alveolar bone height in mice. Increasing intake of carbohydrates reduced alveolar bone height, while dietary protein had no effect. Whether carbohydrate came from sugar or starch did not influence the extent of alveolar bone height. In summary, the amount of carbohydrate in the diet modulated periodontitis-associated alveolar bone height independent of the source of carbohydrates.
AB - While there is a burgeoning interest in the effects of nutrition on systemic inflammatory diseases, how dietary macronutrient balance impacts local chronic inflammatory diseases in the mouth has been largely overlooked. Here, we used the Geometric Framework for Nutrition to test how the amounts of dietary macronutrients and their interactions, as well as carbohydrate type (starch vs sucrose vs resistant starch) influenced periodontitis-associated alveolar bone height in mice. Increasing intake of carbohydrates reduced alveolar bone height, while dietary protein had no effect. Whether carbohydrate came from sugar or starch did not influence the extent of alveolar bone height. In summary, the amount of carbohydrate in the diet modulated periodontitis-associated alveolar bone height independent of the source of carbohydrates.
UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-85062890958&partnerID=MN8TOARS
U2 - 10.1371/journal.pone.0212796
DO - 10.1371/journal.pone.0212796
M3 - Article
SN - 1932-6203
VL - 14
JO - PloS ONE
JF - PloS ONE
IS - 3
M1 - 0212796
ER -