Suicidal ideation in a European Huntington's disease population

Anna A M Hubers, Erik van Duijn, Raymund A C Roos, David Craufurd, Hugh Rickards, G Bernhard Landwehrmeyer, Rose C van der Mast, Erik J Giltay, REGISTRY investigators of the European Huntington's Disease Network, Zofia Helena Miedzybrodzka

Research output: Contribution to journalArticle

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Abstract

BACKGROUND: Previous studies indicate increased prevalences of suicidal ideation, suicide attempts, and completed suicide in Huntington's disease (HD) compared with the general population. This study investigates correlates and predictors of suicidal ideation in HD.

METHODS: The study cohort consisted of 2106 HD mutation carriers, all participating in the REGISTRY study of the European Huntington's Disease Network. Of the 1937 participants without suicidal ideation at baseline, 945 had one or more follow-up measurements. Participants were assessed for suicidal ideation by the behavioural subscale of the Unified Huntington's Disease Rating Scale (UHDRS). Correlates of suicidal ideation were analyzed using logistic regression analysis and predictors were analyzed using Cox regression analysis.

RESULTS: At baseline, 169 (8.0%) mutation carriers endorsed suicidal ideation. Disease duration (odds ratio [OR]=0.96; 95% confidence interval [CI]: 0.9-1.0), anxiety (OR=2.14; 95%CI: 1.4-3.3), aggression (OR=2.41; 95%CI: 1.5-3.8), a previous suicide attempt (OR=3.95; 95%CI: 2.4-6.6), and a depressed mood (OR=13.71; 95%CI: 6.7-28.0) were independently correlated to suicidal ideation at baseline. The 4-year cumulative incidence of suicidal ideation was 9.9%. Longitudinally, the presence of a depressed mood (hazard ratio [HR]=2.05; 95%CI: 1.1-4.0) and use of benzodiazepines (HR=2.44; 95%CI: 1.2-5.0) at baseline were independent predictors of incident suicidal ideation, whereas a previous suicide attempt was not predictive.

LIMITATIONS: As suicidal ideation was assessed by only one item, and participants were a selection of all HD mutation carriers, the prevalence of suicidal ideation was likely underestimated.

CONCLUSIONS: Suicidal ideation in HD frequently occurs. Assessment of suicidal ideation is a priority in mutation carriers with a depressed mood and in those using benzodiazepines.

Original languageEnglish
Pages (from-to)248-58
Number of pages11
JournalJournal of Affective Disorders
Volume151
Issue number1
Early online date20 Jul 2013
DOIs
Publication statusPublished - Oct 2013

Fingerprint

Suicidal Ideation
Huntington Disease
Population
Confidence Intervals
Odds Ratio
Suicide
Mutation
Benzodiazepines
Regression Analysis
Aggression

Keywords

  • Depression
  • Europe
  • Female
  • Heterozygote
  • Humans
  • Huntington Disease
  • Male
  • Middle Aged
  • Prevalence
  • Proportional Hazards Models
  • Psychiatric Status Rating Scales
  • Psychological Tests
  • Suicidal Ideation
  • Suicide, Attempted

Cite this

Hubers, A. A. M., van Duijn, E., Roos, R. A. C., Craufurd, D., Rickards, H., Bernhard Landwehrmeyer, G., ... Miedzybrodzka, Z. H. (2013). Suicidal ideation in a European Huntington's disease population. Journal of Affective Disorders, 151(1), 248-58. https://doi.org/10.1016/j.jad.2013.06.001

Suicidal ideation in a European Huntington's disease population. / Hubers, Anna A M; van Duijn, Erik; Roos, Raymund A C; Craufurd, David; Rickards, Hugh; Bernhard Landwehrmeyer, G; van der Mast, Rose C; Giltay, Erik J; REGISTRY investigators of the European Huntington's Disease Network ; Miedzybrodzka, Zofia Helena.

In: Journal of Affective Disorders, Vol. 151, No. 1, 10.2013, p. 248-58.

Research output: Contribution to journalArticle

Hubers, AAM, van Duijn, E, Roos, RAC, Craufurd, D, Rickards, H, Bernhard Landwehrmeyer, G, van der Mast, RC, Giltay, EJ, REGISTRY investigators of the European Huntington's Disease Network & Miedzybrodzka, ZH 2013, 'Suicidal ideation in a European Huntington's disease population', Journal of Affective Disorders, vol. 151, no. 1, pp. 248-58. https://doi.org/10.1016/j.jad.2013.06.001
Hubers AAM, van Duijn E, Roos RAC, Craufurd D, Rickards H, Bernhard Landwehrmeyer G et al. Suicidal ideation in a European Huntington's disease population. Journal of Affective Disorders. 2013 Oct;151(1):248-58. https://doi.org/10.1016/j.jad.2013.06.001
Hubers, Anna A M ; van Duijn, Erik ; Roos, Raymund A C ; Craufurd, David ; Rickards, Hugh ; Bernhard Landwehrmeyer, G ; van der Mast, Rose C ; Giltay, Erik J ; REGISTRY investigators of the European Huntington's Disease Network ; Miedzybrodzka, Zofia Helena. / Suicidal ideation in a European Huntington's disease population. In: Journal of Affective Disorders. 2013 ; Vol. 151, No. 1. pp. 248-58.
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abstract = "BACKGROUND: Previous studies indicate increased prevalences of suicidal ideation, suicide attempts, and completed suicide in Huntington's disease (HD) compared with the general population. This study investigates correlates and predictors of suicidal ideation in HD.METHODS: The study cohort consisted of 2106 HD mutation carriers, all participating in the REGISTRY study of the European Huntington's Disease Network. Of the 1937 participants without suicidal ideation at baseline, 945 had one or more follow-up measurements. Participants were assessed for suicidal ideation by the behavioural subscale of the Unified Huntington's Disease Rating Scale (UHDRS). Correlates of suicidal ideation were analyzed using logistic regression analysis and predictors were analyzed using Cox regression analysis.RESULTS: At baseline, 169 (8.0{\%}) mutation carriers endorsed suicidal ideation. Disease duration (odds ratio [OR]=0.96; 95{\%} confidence interval [CI]: 0.9-1.0), anxiety (OR=2.14; 95{\%}CI: 1.4-3.3), aggression (OR=2.41; 95{\%}CI: 1.5-3.8), a previous suicide attempt (OR=3.95; 95{\%}CI: 2.4-6.6), and a depressed mood (OR=13.71; 95{\%}CI: 6.7-28.0) were independently correlated to suicidal ideation at baseline. The 4-year cumulative incidence of suicidal ideation was 9.9{\%}. Longitudinally, the presence of a depressed mood (hazard ratio [HR]=2.05; 95{\%}CI: 1.1-4.0) and use of benzodiazepines (HR=2.44; 95{\%}CI: 1.2-5.0) at baseline were independent predictors of incident suicidal ideation, whereas a previous suicide attempt was not predictive.LIMITATIONS: As suicidal ideation was assessed by only one item, and participants were a selection of all HD mutation carriers, the prevalence of suicidal ideation was likely underestimated.CONCLUSIONS: Suicidal ideation in HD frequently occurs. Assessment of suicidal ideation is a priority in mutation carriers with a depressed mood and in those using benzodiazepines.",
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AU - Hubers, Anna A M

AU - van Duijn, Erik

AU - Roos, Raymund A C

AU - Craufurd, David

AU - Rickards, Hugh

AU - Bernhard Landwehrmeyer, G

AU - van der Mast, Rose C

AU - Giltay, Erik J

AU - REGISTRY investigators of the European Huntington's Disease Network

AU - Miedzybrodzka, Zofia Helena

N1 - © 2013 Elsevier B.V. All rights reserved. Acknowledgments The authors thank the NIHR Biomedical Research Centre in Manchester.

PY - 2013/10

Y1 - 2013/10

N2 - BACKGROUND: Previous studies indicate increased prevalences of suicidal ideation, suicide attempts, and completed suicide in Huntington's disease (HD) compared with the general population. This study investigates correlates and predictors of suicidal ideation in HD.METHODS: The study cohort consisted of 2106 HD mutation carriers, all participating in the REGISTRY study of the European Huntington's Disease Network. Of the 1937 participants without suicidal ideation at baseline, 945 had one or more follow-up measurements. Participants were assessed for suicidal ideation by the behavioural subscale of the Unified Huntington's Disease Rating Scale (UHDRS). Correlates of suicidal ideation were analyzed using logistic regression analysis and predictors were analyzed using Cox regression analysis.RESULTS: At baseline, 169 (8.0%) mutation carriers endorsed suicidal ideation. Disease duration (odds ratio [OR]=0.96; 95% confidence interval [CI]: 0.9-1.0), anxiety (OR=2.14; 95%CI: 1.4-3.3), aggression (OR=2.41; 95%CI: 1.5-3.8), a previous suicide attempt (OR=3.95; 95%CI: 2.4-6.6), and a depressed mood (OR=13.71; 95%CI: 6.7-28.0) were independently correlated to suicidal ideation at baseline. The 4-year cumulative incidence of suicidal ideation was 9.9%. Longitudinally, the presence of a depressed mood (hazard ratio [HR]=2.05; 95%CI: 1.1-4.0) and use of benzodiazepines (HR=2.44; 95%CI: 1.2-5.0) at baseline were independent predictors of incident suicidal ideation, whereas a previous suicide attempt was not predictive.LIMITATIONS: As suicidal ideation was assessed by only one item, and participants were a selection of all HD mutation carriers, the prevalence of suicidal ideation was likely underestimated.CONCLUSIONS: Suicidal ideation in HD frequently occurs. Assessment of suicidal ideation is a priority in mutation carriers with a depressed mood and in those using benzodiazepines.

AB - BACKGROUND: Previous studies indicate increased prevalences of suicidal ideation, suicide attempts, and completed suicide in Huntington's disease (HD) compared with the general population. This study investigates correlates and predictors of suicidal ideation in HD.METHODS: The study cohort consisted of 2106 HD mutation carriers, all participating in the REGISTRY study of the European Huntington's Disease Network. Of the 1937 participants without suicidal ideation at baseline, 945 had one or more follow-up measurements. Participants were assessed for suicidal ideation by the behavioural subscale of the Unified Huntington's Disease Rating Scale (UHDRS). Correlates of suicidal ideation were analyzed using logistic regression analysis and predictors were analyzed using Cox regression analysis.RESULTS: At baseline, 169 (8.0%) mutation carriers endorsed suicidal ideation. Disease duration (odds ratio [OR]=0.96; 95% confidence interval [CI]: 0.9-1.0), anxiety (OR=2.14; 95%CI: 1.4-3.3), aggression (OR=2.41; 95%CI: 1.5-3.8), a previous suicide attempt (OR=3.95; 95%CI: 2.4-6.6), and a depressed mood (OR=13.71; 95%CI: 6.7-28.0) were independently correlated to suicidal ideation at baseline. The 4-year cumulative incidence of suicidal ideation was 9.9%. Longitudinally, the presence of a depressed mood (hazard ratio [HR]=2.05; 95%CI: 1.1-4.0) and use of benzodiazepines (HR=2.44; 95%CI: 1.2-5.0) at baseline were independent predictors of incident suicidal ideation, whereas a previous suicide attempt was not predictive.LIMITATIONS: As suicidal ideation was assessed by only one item, and participants were a selection of all HD mutation carriers, the prevalence of suicidal ideation was likely underestimated.CONCLUSIONS: Suicidal ideation in HD frequently occurs. Assessment of suicidal ideation is a priority in mutation carriers with a depressed mood and in those using benzodiazepines.

KW - Depression

KW - Europe

KW - Female

KW - Heterozygote

KW - Humans

KW - Huntington Disease

KW - Male

KW - Middle Aged

KW - Prevalence

KW - Proportional Hazards Models

KW - Psychiatric Status Rating Scales

KW - Psychological Tests

KW - Suicidal Ideation

KW - Suicide, Attempted

U2 - 10.1016/j.jad.2013.06.001

DO - 10.1016/j.jad.2013.06.001

M3 - Article

VL - 151

SP - 248

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JO - Journal of Affective Disorders

JF - Journal of Affective Disorders

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