Supplementation with a 9c,11t-rich conjugated linoleic acid blend shows no clear inhibitory effects on platelet function in healthy subjects at low and moderate cardiovascular risk: A randomized controlled trial

Eva-Maria Bachmair, Sharon G Wood, Hiskias G Keizer, Graham W Horgan, Isobel Ford, Baukje de Roos

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Scope
The 9cis,11trans-conjugated linoleic acid (9c,11t-CLA) is reported to have anti-atherogenic properties in animal models and to modulate protein expression in unstimulated human platelets in vivo. Platelet function was therefore investigated after dietary supplementation with 9c,11t-CLA enriched oil (CLA80:20) in a randomized, baseline-controlled cross-over trial.

Methods and results
Forty-three healthy adults at low to moderate risk of cardiovascular disease received 4 g/day of CLA80:20 or placebo for two weeks each. Platelet function, inflammation, and endothelial activation were assessed before and after each phase. Compared with placebo, supplementation had no significant effects on platelet function measured by Platelet Function Analyzer-100. Inhibitory effects on collagen-induced aggregation were sex-dependent (p = 0.005) that reached significance only in women (p = 0.045). Thrombin receptor-activating peptide (TRAP)-induced P-selectin expression was higher after supplementation in all subjects (p = 0.017). TRAP-induced platelet fibrinogen binding was also dependent on sex (p = 0.015), with fibrinogen binding after CLA80:20 being higher in males (p = 0.035). Plasma monocyte chemoattractant protein-1 was higher (p = 0.041) after CLA80:20.

Conclusion
No clear evidence was found for inhibition or activation of platelet function as well as inflammation by CLA80:20 in a low to moderate cardiovascular risk group.
Original languageEnglish
Pages (from-to)741-750
Number of pages10
JournalMolecular Nutrition & Food Research
Volume59
Issue number4
Early online date23 Feb 2015
DOIs
Publication statusPublished - Apr 2015

Keywords

  • cardiovascular risk
  • platelet function
  • dietary intervention
  • conjugated linoleic acid
  • fatty-acids
  • randomized controlled trial

Fingerprint Dive into the research topics of 'Supplementation with a 9c,11t-rich conjugated linoleic acid blend shows no clear inhibitory effects on platelet function in healthy subjects at low and moderate cardiovascular risk: A randomized controlled trial'. Together they form a unique fingerprint.

  • Cite this