Suppression of HIV Replication by CD8+ Cell Clones Derived from HIV-Infected and Uninfected Individuals

Frank W. Hsueh, Christopher M. Walker, David J. Blackbourn, Jay A. Levy

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)

Abstract

CD8+ cell clones have been derived from peripheral blood mononuclear cells of human immunodeficiency virus (HIV)-infected and uninfected individuals. Several of these cloned cells have the ability to suppress HIV replication when cocultured with CD4+ cells acutely infected in the laboratory with HIV or with infected CD4+ cells from infected subjects. Suppression of virus production occurs without killing the target cells. With the CD8+ cell clones studied, this antiviral response correlated with production of a filterable factor that has antiviral activity. These cell clones offer the opportunity for identification of the factor mediating suppression of HIV replication. Moreover, adoptive transfer of cell clones might provide a valuable therapeutic approach for HIV-infected individuals.

Original languageEnglish
Pages (from-to)271-279
Number of pages9
JournalCellular Immunology
Volume159
Issue number2
DOIs
Publication statusPublished - Dec 1994

Fingerprint

Dive into the research topics of 'Suppression of HIV Replication by CD8<sup>+</sup> Cell Clones Derived from HIV-Infected and Uninfected Individuals'. Together they form a unique fingerprint.

Cite this