Suppression of human immunodeficiency virus type 1 replication by a soluble factor produced by CD8 + lymphocytes from HIV-2-infected baboons

Christopher P. Locher*, David J. Blackbourn, Jay A. Levy

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

Human immunodeficiency virus type 2 (HIV-2)-infected baboons (Papio cynocephalus) provide a valuable animal model for the study of acquired immunodeficiency syndrome (AIDS) pathogenesis since many features of disease progression resemble HIV-1-infection of humans. In some HIV-2-infected baboons that are clinically healthy, a CD8 + cell antiviral response, that is partly mediated by a soluble factor, controls vital replication in vitro. In the present study, we demonstrate that CD8 + cells derived from HIV-2- infected baboon peripheral blood, lymph nodes, adenoids and tonsils had antiviral activity in co-cultures of CD8 + and CD4 + cells that inversely correlates with vital load. A soluble factor was found to be active against the chemokine-resistant, syncytium-inducing HIV-1(SF2) and HIV-1(SF33) isolates and was relatively heat stable at 100°C for 10 min. Moreover, inhibition of the transcription from the long terminal repeat of HIV-1 was observed in IG5 cells after activation with phorbol 12-myristate 13-acetate. Therefore, the soluble suppressing activity of CD8 + cells in HIV-2-infected baboons may be analogous to the CD8 + cell antiviral factor described in human HIV-infected asymptomatic people.

Original languageEnglish
Pages (from-to)151-157
Number of pages7
JournalImmunology Letters
Volume66
Issue number1-3
DOIs
Publication statusPublished - 1 Mar 1999

Keywords

  • AIDS
  • Animal model
  • Baboon
  • CD8+ cell antiviral factor (CAF)
  • Human immunodeficiency virus type-2

Fingerprint

Dive into the research topics of 'Suppression of human immunodeficiency virus type 1 replication by a soluble factor produced by CD8 + lymphocytes from HIV-2-infected baboons'. Together they form a unique fingerprint.

Cite this