Survival, adverse reactions and quality of life during combination chemotherapy compared with selective palliative treatment for small-cell lung cancer: Report to the medical research council by its lung cancer working party

N. M. Bleehen, P. M. Fayers, D. J. Girling*, R. J. Stephens

*Corresponding author for this work

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Two policies of treatment for small-cell lung cancer, both of which have their advocates in the United Kingdom, have been compared in a randomised multicentre study. Of a total of 151 patients, 76 were allocated to immediate combination chemotherapy and radiotherapy, and 75 to selective treatment in which treatment was not necessarily started immediately, but chemotherapy and, or radiotherapy was given as and when required to control symptoms. With the policy of immediate compared with selective treatment, survival was longer (P<0·001, log-rank test), metastases were better controlled, and the quality of life as assessed intermittently by the clinicians was better, but there were more treatment-related deaths, adverse reactions were more common, reactions other than alopecia being reported in 80% compared with 33% (P<0·001) and the quality of life as reported daily by the patients using a diary card was worse.

Original languageEnglish
Pages (from-to)51-58
Number of pages8
JournalRespiratory Medicine
Volume83
Issue number1
DOIs
Publication statusPublished - Jan 1989

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Small Cell Lung Carcinoma
Combination Drug Therapy
Palliative Care
Biomedical Research
Lung Neoplasms
Quality of Life
Survival
Radiotherapy
Therapeutics
Alopecia
Multicenter Studies
Neoplasm Metastasis
Drug Therapy

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

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title = "Survival, adverse reactions and quality of life during combination chemotherapy compared with selective palliative treatment for small-cell lung cancer: Report to the medical research council by its lung cancer working party",
abstract = "Two policies of treatment for small-cell lung cancer, both of which have their advocates in the United Kingdom, have been compared in a randomised multicentre study. Of a total of 151 patients, 76 were allocated to immediate combination chemotherapy and radiotherapy, and 75 to selective treatment in which treatment was not necessarily started immediately, but chemotherapy and, or radiotherapy was given as and when required to control symptoms. With the policy of immediate compared with selective treatment, survival was longer (P<0·001, log-rank test), metastases were better controlled, and the quality of life as assessed intermittently by the clinicians was better, but there were more treatment-related deaths, adverse reactions were more common, reactions other than alopecia being reported in 80{\%} compared with 33{\%} (P<0·001) and the quality of life as reported daily by the patients using a diary card was worse.",
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AB - Two policies of treatment for small-cell lung cancer, both of which have their advocates in the United Kingdom, have been compared in a randomised multicentre study. Of a total of 151 patients, 76 were allocated to immediate combination chemotherapy and radiotherapy, and 75 to selective treatment in which treatment was not necessarily started immediately, but chemotherapy and, or radiotherapy was given as and when required to control symptoms. With the policy of immediate compared with selective treatment, survival was longer (P<0·001, log-rank test), metastases were better controlled, and the quality of life as assessed intermittently by the clinicians was better, but there were more treatment-related deaths, adverse reactions were more common, reactions other than alopecia being reported in 80% compared with 33% (P<0·001) and the quality of life as reported daily by the patients using a diary card was worse.

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