Susceptibility of corneal allografts and xenografts to antibody-mediated rejection

V. Holan, A. Vitova, M. Krulova, A. Zajicova, A. Neuwirth, M. Filipec, John Vincent Forrester

Research output: Contribution to journalLetter

12 Citations (Scopus)

Abstract

The effects of passive transfer of antisera containing cytotoxic antibodies to allo- and xenoantigens on survival of corneal allografts and xenografts were evaluated in experimental models. Corneas from allogeneic B 10 or xenogeneic rat Lewis donors were grafted orthotopically into BALB/c mice. Recipient mice were treated with donor-specific antisera administered at the period of grafting or at 2 weeks after transplantation. Rejection was determined by the severity of corneal opacity using a standard scoring system. Treatment of graft recipients with donor-specific antisera accelerated the onset of graft rejection and significantly shortened survival times of both corneal allografts and xenografts. Corneal xenografts, which had been accepted after treatment with anti-CD4 monoclonal antibody, were acutely rejected by the passive transfer of antiserum against xenoantigens. The results suggest that corneal grafts are vulnerable to antibody-dependent immunity and that cytotoxic antibodies against graft donor antigens can mediate rejection of both corneal allografts and xenografts. (c) 2005 Elsevier B.V. All rights reserved.

Original languageEnglish
Pages (from-to)211-213
Number of pages2
JournalImmunology Letters
Volume100
Issue number2
DOIs
Publication statusPublished - 2005

Keywords

  • corneal transplantation
  • allografts
  • xenografts
  • antibodies
  • graft rejection
  • GRAFT-REJECTION
  • MOUSE MODEL
  • TRANSPLANTATION
  • RAT
  • DESTRUCTION
  • CELLS

Cite this

Holan, V., Vitova, A., Krulova, M., Zajicova, A., Neuwirth, A., Filipec, M., & Forrester, J. V. (2005). Susceptibility of corneal allografts and xenografts to antibody-mediated rejection. Immunology Letters, 100(2), 211-213. https://doi.org/10.1016/j.imlet.2005.03.013

Susceptibility of corneal allografts and xenografts to antibody-mediated rejection. / Holan, V.; Vitova, A.; Krulova, M.; Zajicova, A.; Neuwirth, A.; Filipec, M.; Forrester, John Vincent.

In: Immunology Letters, Vol. 100, No. 2, 2005, p. 211-213.

Research output: Contribution to journalLetter

Holan, V, Vitova, A, Krulova, M, Zajicova, A, Neuwirth, A, Filipec, M & Forrester, JV 2005, 'Susceptibility of corneal allografts and xenografts to antibody-mediated rejection' Immunology Letters, vol. 100, no. 2, pp. 211-213. https://doi.org/10.1016/j.imlet.2005.03.013
Holan V, Vitova A, Krulova M, Zajicova A, Neuwirth A, Filipec M et al. Susceptibility of corneal allografts and xenografts to antibody-mediated rejection. Immunology Letters. 2005;100(2):211-213. https://doi.org/10.1016/j.imlet.2005.03.013
Holan, V. ; Vitova, A. ; Krulova, M. ; Zajicova, A. ; Neuwirth, A. ; Filipec, M. ; Forrester, John Vincent. / Susceptibility of corneal allografts and xenografts to antibody-mediated rejection. In: Immunology Letters. 2005 ; Vol. 100, No. 2. pp. 211-213.
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abstract = "The effects of passive transfer of antisera containing cytotoxic antibodies to allo- and xenoantigens on survival of corneal allografts and xenografts were evaluated in experimental models. Corneas from allogeneic B 10 or xenogeneic rat Lewis donors were grafted orthotopically into BALB/c mice. Recipient mice were treated with donor-specific antisera administered at the period of grafting or at 2 weeks after transplantation. Rejection was determined by the severity of corneal opacity using a standard scoring system. Treatment of graft recipients with donor-specific antisera accelerated the onset of graft rejection and significantly shortened survival times of both corneal allografts and xenografts. Corneal xenografts, which had been accepted after treatment with anti-CD4 monoclonal antibody, were acutely rejected by the passive transfer of antiserum against xenoantigens. The results suggest that corneal grafts are vulnerable to antibody-dependent immunity and that cytotoxic antibodies against graft donor antigens can mediate rejection of both corneal allografts and xenografts. (c) 2005 Elsevier B.V. All rights reserved.",
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AU - Holan, V.

AU - Vitova, A.

AU - Krulova, M.

AU - Zajicova, A.

AU - Neuwirth, A.

AU - Filipec, M.

AU - Forrester, John Vincent

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AB - The effects of passive transfer of antisera containing cytotoxic antibodies to allo- and xenoantigens on survival of corneal allografts and xenografts were evaluated in experimental models. Corneas from allogeneic B 10 or xenogeneic rat Lewis donors were grafted orthotopically into BALB/c mice. Recipient mice were treated with donor-specific antisera administered at the period of grafting or at 2 weeks after transplantation. Rejection was determined by the severity of corneal opacity using a standard scoring system. Treatment of graft recipients with donor-specific antisera accelerated the onset of graft rejection and significantly shortened survival times of both corneal allografts and xenografts. Corneal xenografts, which had been accepted after treatment with anti-CD4 monoclonal antibody, were acutely rejected by the passive transfer of antiserum against xenoantigens. The results suggest that corneal grafts are vulnerable to antibody-dependent immunity and that cytotoxic antibodies against graft donor antigens can mediate rejection of both corneal allografts and xenografts. (c) 2005 Elsevier B.V. All rights reserved.

KW - corneal transplantation

KW - allografts

KW - xenografts

KW - antibodies

KW - graft rejection

KW - GRAFT-REJECTION

KW - MOUSE MODEL

KW - TRANSPLANTATION

KW - RAT

KW - DESTRUCTION

KW - CELLS

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JF - Immunology Letters

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