Susceptibility of corneal allografts and xenografts to antibody-mediated rejection

V. Holan, A. Vitova, M. Krulova, A. Zajicova, A. Neuwirth, M. Filipec, John Vincent Forrester

Research output: Contribution to journalLetter

12 Citations (Scopus)

Abstract

The effects of passive transfer of antisera containing cytotoxic antibodies to allo- and xenoantigens on survival of corneal allografts and xenografts were evaluated in experimental models. Corneas from allogeneic B 10 or xenogeneic rat Lewis donors were grafted orthotopically into BALB/c mice. Recipient mice were treated with donor-specific antisera administered at the period of grafting or at 2 weeks after transplantation. Rejection was determined by the severity of corneal opacity using a standard scoring system. Treatment of graft recipients with donor-specific antisera accelerated the onset of graft rejection and significantly shortened survival times of both corneal allografts and xenografts. Corneal xenografts, which had been accepted after treatment with anti-CD4 monoclonal antibody, were acutely rejected by the passive transfer of antiserum against xenoantigens. The results suggest that corneal grafts are vulnerable to antibody-dependent immunity and that cytotoxic antibodies against graft donor antigens can mediate rejection of both corneal allografts and xenografts. (c) 2005 Elsevier B.V. All rights reserved.

Original languageEnglish
Pages (from-to)211-213
Number of pages2
JournalImmunology Letters
Volume100
Issue number2
DOIs
Publication statusPublished - 2005

Keywords

  • corneal transplantation
  • allografts
  • xenografts
  • antibodies
  • graft rejection
  • GRAFT-REJECTION
  • MOUSE MODEL
  • TRANSPLANTATION
  • RAT
  • DESTRUCTION
  • CELLS

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