Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 86-90 |
| Number of pages | 5 |
| Journal | International Journal of Antimicrobial Agents |
| Volume | 48 |
| Issue number | 1 |
| Early online date | 17 May 2016 |
| DOIs | |
| Publication status | Published - Jul 2016 |
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Keywords
- chlorhexidine baths
- intensive therapy unit
- Staphylococcus aureus
- Staphylococcus epidermidis
- gac genes
- multidrug resistance
- ST-2
Cite this
Susceptibility to chlorhexidine amongst multidrug-resistant clinical isolates of Staphylococcus epidermidis from bloodstream infections. / Hijazi, Karolin; Mukhopadhya, Indrani; Abbott, Felicity; Milne, Kathleen ; Al-Jabri, Zaaima J; Oggioni, Marco R; Gould, Ian M.
In: International Journal of Antimicrobial Agents, Vol. 48, No. 1, 07.2016, p. 86-90.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Susceptibility to chlorhexidine amongst multidrug-resistant clinical isolates of Staphylococcus epidermidis from bloodstream infections
AU - Hijazi, Karolin
AU - Mukhopadhya, Indrani
AU - Abbott, Felicity
AU - Milne, Kathleen
AU - Al-Jabri, Zaaima J
AU - Oggioni, Marco R
AU - Gould, Ian M
N1 - We thank the staff of the Aberdeen Clinical Diagnostic Laboratory and the Centre for Genome-Enabled Biology and Medicine of the University of Aberdeen for their dedicated support to this study.
PY - 2016/7
Y1 - 2016/7
N2 - Emergence of Staphylococcus isolates with reduced susceptibility to chlorhexidine is being increasingly reported. We present an update to a previous report showing continuing efficacy of chlorhexidine-based infection control measures against Staphylococcus aureus over six years. We screened qacA/B genes in Staphylococcus isolates collected over another six years in the same intensive therapy unit in Scotland where chlorhexidine baths form an essential component of long-term control of nosocomial infections. Consistent with our previous study we report minimal presence of qacA/B in S. aureus strains from screening samples and bacteraemia patients but the new finding of a high proportion of qacA/B carriage in Staphylococcus epidermidis associated to reduced susceptibility to chlorhexidine. S. epidermidis isolates positive for qacA/B were clonally diverse although 65% of isolates belonged to the multidrug resistant clone ST-2. These findings raise concerns in relation to selection of multidrug resistant strains by chlorhexidine and are important in the context of recent evidence emphasising the benefits of targeting bloodstream infections associated with coagulase-negative staphylococci.
AB - Emergence of Staphylococcus isolates with reduced susceptibility to chlorhexidine is being increasingly reported. We present an update to a previous report showing continuing efficacy of chlorhexidine-based infection control measures against Staphylococcus aureus over six years. We screened qacA/B genes in Staphylococcus isolates collected over another six years in the same intensive therapy unit in Scotland where chlorhexidine baths form an essential component of long-term control of nosocomial infections. Consistent with our previous study we report minimal presence of qacA/B in S. aureus strains from screening samples and bacteraemia patients but the new finding of a high proportion of qacA/B carriage in Staphylococcus epidermidis associated to reduced susceptibility to chlorhexidine. S. epidermidis isolates positive for qacA/B were clonally diverse although 65% of isolates belonged to the multidrug resistant clone ST-2. These findings raise concerns in relation to selection of multidrug resistant strains by chlorhexidine and are important in the context of recent evidence emphasising the benefits of targeting bloodstream infections associated with coagulase-negative staphylococci.
KW - chlorhexidine baths
KW - intensive therapy unit
KW - Staphylococcus aureus
KW - Staphylococcus epidermidis
KW - gac genes
KW - multidrug resistance
KW - ST-2
U2 - 10.1016/j.ijantimicag.2016.04.015
DO - 10.1016/j.ijantimicag.2016.04.015
M3 - Article
VL - 48
SP - 86
EP - 90
JO - International Journal of Antimicrobial Agents
JF - International Journal of Antimicrobial Agents
SN - 0924-8579
IS - 1
ER -