SWATted away: the challenging experience of setting up a programme of SWATs in paediatric trials

Jacqueline Martin-Kerry (Corresponding Author), Adwoa Parker, Peter Bower, Ian Watt, Shaun Treweek, David Torgerson, Catherine Arundel, Peter Knapp

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Abstract

Randomised controlled trials are considered the best method for determining the effectiveness and safety of health interventions. Trials involving children are essential to ensure that treatments are safe and effective. However, many trials, in both adult and paediatric populations, do not achieve recruitment targets and/or maintain retention of participants, which can lead to a reduction in the internal and external validity of the results. Identifying ways of improving trial efficiency are important in order to increase the successful completion of trials.
Original languageEnglish
Article number141
JournalTrials
Volume20
Issue number1
DOIs
Publication statusPublished - 19 Feb 2019

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Keywords

  • ‘SStudy Within A Trial’ (SWAT)
  • embedded trials
  • methodology
  • challenges
  • randomised controlled trials
  • paediatrics
  • governance
  • 'SStudy Within A Trial' (SWAT)

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Medicine (miscellaneous)

Cite this

Martin-Kerry, J., Parker, A., Bower, P., Watt, I., Treweek, S., Torgerson, D., Arundel, C., & Knapp, P. (2019). SWATted away: the challenging experience of setting up a programme of SWATs in paediatric trials. Trials, 20(1), [141]. https://doi.org/10.1186/s13063-019-3236-4