Syk-coupled C-type lectin receptors that mediate cellular activation via single tyrosine based activation motifs

Ann M. Kerrigan, Gordon D. Brown

Research output: Contribution to journalArticle

110 Citations (Scopus)

Abstract

Different dendritic cell (DC) subsets have distinct specialized functions contributed in part by their differential expression of pattern recognition receptors (PRRs). C-type lectin receptors (CLRs) are a group of PRRs expressed by DCs and other myeloid cells that can recognize endogenous ligands as well as a wide range of exogenous structures present on pathogens. Dual roles in homeostasis and immunity have been demonstrated for some members of this receptor family. Largely due to their endocytic ability and subset specific expression, DC-expressed CLRs have been the focus of significant antigen-targeting studies. A number of CLRs function on the basis of signaling via association with immunoreceptor tyrosine-based activation motif (ITAM)-containing adapter proteins. Others contain ITAM-related motifs or immunoreceptor tyrosine-based inhibitory motifs (ITIMs) in their cytoplasmic tails. Here we review CLRs that induce intracellular signaling via a single tyrosine-based ITAM-like motif and highlight their relevance in terms of DC function.
Original languageEnglish
Pages (from-to)335-352
Number of pages18
JournalImmunological Reviews
Volume234
Issue number1
Early online date22 Feb 2010
DOIs
Publication statusPublished - 1 Mar 2010

Keywords

  • pattern recognition receptors
  • C-type lectins
  • fungal infections
  • syk
  • dectin-1

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