Symposium 4: Hot topics in parenteral nutrition Current evidence and ongoing trials on the use of glutamine in critically-ill patients and patients undergoing surgery

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Abstract

The amino acid glutamine has numerous important roles including particularly antioxidant defence, immune function, the inflammatory response, acid-base balance and N economy. The present systematic review of randomised controlled trials of nutrition support with glutamine Lip to August 2008 has found that parenteral glutamine in critical illness is associated with a non-significant reduction in mortality (risk ratio 0-71 (95% CI 0.49, 1.03)) and may reduce infections. However, poor study quality and the possibility of publication bias mean that these results should be interpreted with caution. There is no evidence to suggest that glutamine is harmful in terms of organ failure and parenteral glutamine may reduce the development of organ failure.

Original languageEnglish
Pages (from-to)261-268
Number of pages8
JournalProceedings of the Nutrition Society
Volume68
Issue number3
DOIs
Publication statusPublished - Aug 2009

Keywords

  • Glutamine
  • Systematic review
  • Critical illness
  • PROSPECTIVE RANDOMIZED-TRIAL
  • SEVERE ACUTE-PANCREATITIS
  • MAJOR ABDOMINAL-SURGERY
  • INFECTIOUS MORBIDITY
  • DOUBLE-BLIND
  • ENTERAL NUTRITION
  • SURGICAL-PATIENTS
  • CRITICAL ILLNESS
  • ALANYL-GLUTAMINE
  • CRITICAL-CARE
  • Critial illness
  • Parenteral nutrition
  • Surgical procedures
  • Operative

Cite this

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title = "Symposium 4: Hot topics in parenteral nutrition Current evidence and ongoing trials on the use of glutamine in critically-ill patients and patients undergoing surgery",
abstract = "The amino acid glutamine has numerous important roles including particularly antioxidant defence, immune function, the inflammatory response, acid-base balance and N economy. The present systematic review of randomised controlled trials of nutrition support with glutamine Lip to August 2008 has found that parenteral glutamine in critical illness is associated with a non-significant reduction in mortality (risk ratio 0-71 (95{\%} CI 0.49, 1.03)) and may reduce infections. However, poor study quality and the possibility of publication bias mean that these results should be interpreted with caution. There is no evidence to suggest that glutamine is harmful in terms of organ failure and parenteral glutamine may reduce the development of organ failure.",
keywords = "Glutamine, Systematic review, Critical illness, PROSPECTIVE RANDOMIZED-TRIAL, SEVERE ACUTE-PANCREATITIS, MAJOR ABDOMINAL-SURGERY, INFECTIOUS MORBIDITY, DOUBLE-BLIND, ENTERAL NUTRITION, SURGICAL-PATIENTS, CRITICAL ILLNESS, ALANYL-GLUTAMINE, CRITICAL-CARE, Critial illness, Parenteral nutrition, Surgical procedures, Operative",
author = "Alison Avenell",
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doi = "10.1017/S0029665109001372",
language = "English",
volume = "68",
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AB - The amino acid glutamine has numerous important roles including particularly antioxidant defence, immune function, the inflammatory response, acid-base balance and N economy. The present systematic review of randomised controlled trials of nutrition support with glutamine Lip to August 2008 has found that parenteral glutamine in critical illness is associated with a non-significant reduction in mortality (risk ratio 0-71 (95% CI 0.49, 1.03)) and may reduce infections. However, poor study quality and the possibility of publication bias mean that these results should be interpreted with caution. There is no evidence to suggest that glutamine is harmful in terms of organ failure and parenteral glutamine may reduce the development of organ failure.

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KW - Parenteral nutrition

KW - Surgical procedures

KW - Operative

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