Abstract
The analgesic properties of cannabinoid receptor agonists are well characterized. However, numerous side effects limit the therapeutic potential of these agents. Here we report a synergistic antinociceptive interaction between the endogenous cannabinoid receptor agonist anandamide and the synthetic peroxisome proliferator-activated receptor-alpha (PPAR-alpha) agonist 2-(4-(2-(1-Cyclohexanebutyl)-3-cyclohexylureido)ethyl)phenylthio)-2-methylpropionic acid (GW7647) in a model of acute chemical-induced pain. Moreover, we show that anandamide synergistically interacts with the large-conductance potassium channel (KCa1.1, BK) activator isopimaric acid. These findings reveal a synergistic interaction between the endocannabinoid and PPAR-alpha systems that might be exploited clinically and identify a new pharmacological effect of the BK channel activator isopimaric acid.
| Original language | English |
|---|---|
| Pages (from-to) | 117-119 |
| Number of pages | 3 |
| Journal | European Journal of Pharmacology |
| Volume | 566 |
| Issue number | 1-3 |
| Early online date | 19 Mar 2007 |
| DOIs | |
| Publication status | Published - 2 Jul 2007 |
Keywords
- Analgesics
- Animals
- Arachidonic Acids
- Behavior, Animal
- Butyrates
- Cannabinoid Receptor Agonists
- Drug Synergism
- Endocannabinoids
- Formaldehyde
- Male
- Mice
- PPAR alpha
- Pain
- Phenylurea Compounds
- Polyunsaturated Alkamides
- Cannabinoid
- Palmitoylethanolamide
- Isopimaric acid
- Formalin