Synoxazolidinone C; A bicyclic member of the synoxazolidinone family with antibacterial and anticancer activities

Margey Tadesse* (Corresponding Author), Johan Svenson, Marcel Jaspars, Morten B. Strøm, Mostafa H. Abdelrahman, Jeanette H. Andersen, Espen Hansen, Per E. Kristiansen, Klara Stensvg, Tor Haug

*Corresponding author for this work

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Synoxazolidinone C is a new member of the synoxazolidinone family of compounds which are dibrominated guanidinium 4-oxazolidinones isolated from the sub-Arctic ascidian Synoicum pulmonaria. The compound was isolated along with synoxazolidinones A and B from the same ascidian extract. Spectroscopic methods revealed that the synoxazolidinone C differed from the other synoxazolidinones by an unprecedented bicyclic partial structure, containing an additional pyrrolidine ring. Synoxazolidinone C exhibited both antibacterial and anticancer activities.

Original languageEnglish
Pages (from-to)1804-1806
Number of pages3
JournalTetrahedron Letters
Volume52
Issue number15
Early online date10 Feb 2011
DOIs
Publication statusPublished - 13 Apr 2011

Fingerprint

Urochordata
Pulmonaria
Oxazolidinones
Guanidine
synoxazolidinone C
synoxazolidinone B
synoxazolidinone A
pyrrolidine

Keywords

  • 4-Oxazolidinone
  • Antibacterial
  • Anticancer
  • Synoicum pulmonaria
  • Synoxazolidinone

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this

Synoxazolidinone C; A bicyclic member of the synoxazolidinone family with antibacterial and anticancer activities. / Tadesse, Margey (Corresponding Author); Svenson, Johan; Jaspars, Marcel; Strøm, Morten B.; Abdelrahman, Mostafa H.; Andersen, Jeanette H.; Hansen, Espen; Kristiansen, Per E.; Stensvg, Klara; Haug, Tor.

In: Tetrahedron Letters, Vol. 52, No. 15, 13.04.2011, p. 1804-1806.

Research output: Contribution to journalArticle

Tadesse, M, Svenson, J, Jaspars, M, Strøm, MB, Abdelrahman, MH, Andersen, JH, Hansen, E, Kristiansen, PE, Stensvg, K & Haug, T 2011, 'Synoxazolidinone C; A bicyclic member of the synoxazolidinone family with antibacterial and anticancer activities', Tetrahedron Letters, vol. 52, no. 15, pp. 1804-1806. https://doi.org/10.1016/j.tetlet.2011.02.027
Tadesse, Margey ; Svenson, Johan ; Jaspars, Marcel ; Strøm, Morten B. ; Abdelrahman, Mostafa H. ; Andersen, Jeanette H. ; Hansen, Espen ; Kristiansen, Per E. ; Stensvg, Klara ; Haug, Tor. / Synoxazolidinone C; A bicyclic member of the synoxazolidinone family with antibacterial and anticancer activities. In: Tetrahedron Letters. 2011 ; Vol. 52, No. 15. pp. 1804-1806.
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