Synoxazolidinone C; A bicyclic member of the synoxazolidinone family with antibacterial and anticancer activities

Margey Tadesse* (Corresponding Author), Johan Svenson, Marcel Jaspars, Morten B. Strøm, Mostafa H. Abdelrahman, Jeanette H. Andersen, Espen Hansen, Per E. Kristiansen, Klara Stensvg, Tor Haug

*Corresponding author for this work

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Synoxazolidinone C is a new member of the synoxazolidinone family of compounds which are dibrominated guanidinium 4-oxazolidinones isolated from the sub-Arctic ascidian Synoicum pulmonaria. The compound was isolated along with synoxazolidinones A and B from the same ascidian extract. Spectroscopic methods revealed that the synoxazolidinone C differed from the other synoxazolidinones by an unprecedented bicyclic partial structure, containing an additional pyrrolidine ring. Synoxazolidinone C exhibited both antibacterial and anticancer activities.

Original languageEnglish
Pages (from-to)1804-1806
Number of pages3
JournalTetrahedron Letters
Volume52
Issue number15
Early online date10 Feb 2011
DOIs
Publication statusPublished - 13 Apr 2011

Keywords

  • 4-Oxazolidinone
  • Antibacterial
  • Anticancer
  • Synoicum pulmonaria
  • Synoxazolidinone

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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    Tadesse, M., Svenson, J., Jaspars, M., Strøm, M. B., Abdelrahman, M. H., Andersen, J. H., Hansen, E., Kristiansen, P. E., Stensvg, K., & Haug, T. (2011). Synoxazolidinone C; A bicyclic member of the synoxazolidinone family with antibacterial and anticancer activities. Tetrahedron Letters, 52(15), 1804-1806. https://doi.org/10.1016/j.tetlet.2011.02.027