Synoxazolidinones A and B: Novel Bioactive Alkaloids from the Ascidian Synoicum pulmonaria

Margey Tadesse, Morten B. Strom, Johan Svenson, Marcel Jaspars, Bruce Forbes Milne, Veronika Torfoss, Jeanette H. Andersen, Espen Hansen, Klara Stensvag, Tor Haug

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Abstract

Bioassay-guided fractionation of the sub-Arctic ascidian Synoicum pulmonaria collected off the Norwegian coast led to the isolation of a novel family of brominated guanidinium oxazolidinones named synoxazolidinones A and B (1 and 2). The backbone of the compounds contains a 4-oxazolidinone ring rarely seen in natural products. The structure of the compounds was determined by spectroscopic methods. The synoxazolidinones exhibited antibacterial and antifungal activities.

Original languageEnglish
Pages (from-to)4752-4755
Number of pages4
JournalOrganic Letters
Volume12
Issue number21
Early online date30 Sep 2010
DOIs
Publication statusPublished - 5 Nov 2010

Keywords

  • ANTIBACTERIAL
  • ADAREANUM

Cite this

Tadesse, M., Strom, M. B., Svenson, J., Jaspars, M., Milne, B. F., Torfoss, V., Andersen, J. H., Hansen, E., Stensvag, K., & Haug, T. (2010). Synoxazolidinones A and B: Novel Bioactive Alkaloids from the Ascidian Synoicum pulmonaria. Organic Letters, 12(21), 4752-4755. https://doi.org/10.1021/ol101707u