Abstract
A series of analogues of the integrin binding aspartic acid-glycine-arginine (RGD) peptide sequence were synthesised conjugated to nitric oxide (NO) donating functional groups. Also the cytotoxicity of abiraterone, a prostate cancer drug, was explored when it was conjugated in three part constructs to RGD sequences and NO releasing heterocycles. In general the analogues showed integrin binding affinity
comparable to RGD reference compounds, and all released NO by the Griess test assay. Two analogues exhibited significant cytotoxic effects against PC3 and MCF7 cell lines
comparable to RGD reference compounds, and all released NO by the Griess test assay. Two analogues exhibited significant cytotoxic effects against PC3 and MCF7 cell lines
Original language | English |
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Pages (from-to) | 8343-8347 |
Number of pages | 5 |
Journal | Tetrahedron |
Volume | 70 |
Issue number | 44 |
Early online date | 6 Sep 2014 |
DOIs | |
Publication status | Published - 4 Nov 2014 |
Keywords
- anticancer
- RGD peptide
- nitric oxide
- abiraterone