Enantiomers of α-fluorinated capsaicin 2, have been prepared by organocatalytic electrophilic fluorination and have been used as probes for the binding conformation of capsaicin to the TRPV1 pain receptor. No enantiomeric bias is observed, thus suggesting an extended binding conformation along the molecular axis.
|Number of pages||6|
|Early online date||6 Mar 2009|
|Publication status||Published - 23 Mar 2009|
- fluorinated ligands
- medicinal chemistry
- stereoselective catalysis